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Abstract
Childhood HBV immunization remains globally fundamental to the elimination of hepatitis B virus (HBV). However, monitoring proportions of HBV vaccine seroprotection and their determinants among African Pediatric recipients is crucial. This study sought to verify extent of immune protection accorded by the HBV vaccine in African children of up to 17 years of age by pooling the prevalence of seroprotection reported by primary studies conducted in the Northern, Western, and Southern African regions. We included 19 eligible articles out of the 197 initially downloaded, published from 1999 to 2021 from African Journals Online (AJOL), EMBASE, Scopus, and PubMed. The study protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO), University of York Centre for Reviews and Dissemination, under the registration number CRD42022361277. Significantly higher (p < 0.0001) proportion of HBV vaccine seroprotection (69.07%) was found among children under 15 years of age than children 15–17 years (32.368%), 95% CI [34.2454–39.0847%]. Whereas successful integration of the HBV vaccine on the extended programs on immunizations (EPI) has been a major achievement in the reduction of HBV infection in Africa, markedly reduced HBV vaccine seroprotection is persistently demonstrated among adolescent children 15–17 years of age. Future studies are required to clarify the need for booster dose vaccination in most at risk populations and age groups.
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1 Islamic University in Uganda, Department of Medical Microbiology, Faculty of Health Sciences, Habib Medical School, Kampala, Uganda (GRID:grid.442655.4) (ISNI:0000 0001 0042 4901); Makerere University, Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Kampala, Uganda (GRID:grid.11194.3c) (ISNI:0000 0004 0620 0548)
2 Makerere University, Department of Medical Microbiology, School of Biomedical Sciences, College of Health Sciences, Kampala, Uganda (GRID:grid.11194.3c) (ISNI:0000 0004 0620 0548)
3 Makerere University, Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Kampala, Uganda (GRID:grid.11194.3c) (ISNI:0000 0004 0620 0548); Makerere University, The African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, College of Health Sciences, Kampala, Uganda (GRID:grid.11194.3c) (ISNI:0000 0004 0620 0548)
4 Makerere University, Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Kampala, Uganda (GRID:grid.11194.3c) (ISNI:0000 0004 0620 0548)
5 Makerere University, Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Kampala, Uganda (GRID:grid.11194.3c) (ISNI:0000 0004 0620 0548)
6 Islamic University in Uganda, Department of Medical Microbiology, Faculty of Health Sciences, Habib Medical School, Kampala, Uganda (GRID:grid.442655.4) (ISNI:0000 0001 0042 4901); Makerere University, Department of Medical Microbiology, School of Biomedical Sciences, College of Health Sciences, Kampala, Uganda (GRID:grid.11194.3c) (ISNI:0000 0004 0620 0548)