Abstract

Tests of human brain circuit function typically require fixed equipment in lab environments. We have developed a smartphone-based platform for neurometric testing. This platform, which uses AI models like computer vision, is optimized for at-home use and produces reproducible, robust results on a battery of tests, including eyeblink conditioning, prepulse inhibition of acoustic startle response, and startle habituation. This approach provides a scalable, universal resource for quantitative assays of central nervous system function.

Details

Title
Accessible and reliable neurometric testing in humans using a smartphone platform
Author
Boele, H. J. 1 ; Jung, C. 2 ; Sherry, S. 2 ; Roggeveen, L. E. M. 3 ; Dijkhuizen, S. 4 ; Öhman, J. 5 ; Abraham, E. 2 ; Uvarov, A. 6 ; Boele, C. P. 4 ; Gultig, K. 4 ; Rasmussen, A. 5 ; Vinueza-Veloz, M. F. 7 ; Medina, J. F. 8 ; Koekkoek, S. K. E. 4 ; De Zeeuw, C. I. 9 ; Wang, S. S. -H. 2 

 Princeton Neuroscience Institute, Princeton, USA (GRID:grid.16750.35) (ISNI:0000 0001 2097 5006); Erasmus MC, Department of Neuroscience, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:0000 0004 0459 992X) 
 Princeton Neuroscience Institute, Princeton, USA (GRID:grid.16750.35) (ISNI:0000 0001 2097 5006) 
 Erasmus MC, Department of Neuroscience, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:0000 0004 0459 992X); Vrije Universiteit, Department of Neuroscience, Amsterdam, The Netherlands (GRID:grid.12380.38) (ISNI:0000 0004 1754 9227) 
 Erasmus MC, Department of Neuroscience, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:0000 0004 0459 992X) 
 Lund University, Department of Clinical Sciences, Lund, Sweden (GRID:grid.4514.4) (ISNI:0000 0001 0930 2361) 
 BlinkLab Pty, Sydney, Australia (GRID:grid.16750.35) 
 Erasmus MC, Department of Neuroscience, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:0000 0004 0459 992X); University of Oslo, Department of Community Medicine and Global Health, Oslo, Norway (GRID:grid.5510.1) (ISNI:0000 0004 1936 8921) 
 Baylor College of Medicine, Department of Neuroscience, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X) 
 Erasmus MC, Department of Neuroscience, Rotterdam, The Netherlands (GRID:grid.5645.2) (ISNI:0000 0004 0459 992X); Royal Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands (GRID:grid.419918.c) (ISNI:0000 0001 2171 8263) 
Pages
22871
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2904488271
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.