Full text

Turn on search term navigation

© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This paper delineates several aspects of cystic fibrosis-related diabetes (CFRD)—a common complication of cystic fibrosis (CF). CFRD exhibits a predilection for older individuals with CF, yet it also extends its influence on children and adolescents. Scientific insights postulate a potential link between CFRD and the aberrant mucus production within the pancreas, thereby culminating in pancreatic insufficiency. This, in turn, perturbs the synthesis of insulin, a pivotal endocrine hormone responsible for the regulation of glycemic levels. Standardized protocols advocate for the systematic screening of CFRD among all individuals with CF, commencing at the age of 10 years using the oral glucose tolerance test (OGTT). Therapeutic modalities encompass insulin therapy, dietary adjustments, and the vigilant monitoring of glycemic parameters. The overarching objective is to maintain blood glucose levels within a targeted range to mitigate the advent of diabetic complications. Untreated or sub-optimally managed CFRD can precipitate a spectrum of deleterious health ramifications, encompassing cardiovascular afflictions, neuropathy, renal dysfunction, and ocular complications.

Details

Title
An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents
Author
Anton-Păduraru, Dana-Teodora 1   VIAFID ORCID Logo  ; Murgu, Alina Mariela 1 ; Mădălina Andreea Donos 1 ; Trofin, Felicia 2   VIAFID ORCID Logo  ; Azoicăi, Alice Nicoleta 1 ; Popovici, Paula 1 ; Aurelian, Bogdan Stana 1 ; Gheorghiescu, Ionela 3 ; Trandafir, Laura Mihaela 1 

 Department of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; [email protected] (D.-T.A.-P.); [email protected] (A.M.M.); [email protected] (A.N.A.); [email protected] (P.P.); [email protected] (A.B.S.); [email protected] (L.M.T.); “Sf. Maria” Children Emergency Hospital, 700309 Iasi, Romania 
 Department of Preventive Medicine and Interdisciplinarity—Microbiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; [email protected]; Clinical Hospital of Infectious Diseases “Sf. Parascheva”, 700116 Iasi, Romania 
 Faculty of General Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; [email protected] 
First page
1879
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
22279067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2904700018
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.