Abstract

This study investigated the utility of periostin, a matricellular protein, as a prognostic biomarker in patients with idiopathic pulmonary fibrosis (IPF) who received nintedanib. Monomeric and total periostin levels were measured by enzyme-linked immunosorbent assay in 87 eligible patients who participated in a multicenter prospective study. Forty-three antifibrotic drug-naive patients with IPF described in previous studies were set as historical controls. Monomeric and total periostin levels were not significantly associated with the change in forced vital capacity (FVC) or diffusing capacity of the lungs for carbon monoxide (DLCO) during any follow-up period. Higher monomeric and total periostin levels were independent risk factors for overall survival in the Cox proportional hazard model. In the analysis of nintedanib effectiveness, higher binarized monomeric periostin levels were associated with more favorable suppressive effects on decreased vital capacity (VC) and DLCO in the treatment group compared with historical controls. Higher binarized levels of total periostin were associated with more favorable suppressive effects on decreased DLCO but not VC. In conclusion, higher periostin levels were independently associated with survival and better therapeutic effectiveness in patients with IPF treated with nintedanib. Periostin assessments may contribute to determining therapeutic strategies for patients with IPF.

Details

Title
A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib
Author
Okamoto, Masaki 1 ; Fujimoto, Kiminori 2 ; Johkoh, Takeshi 3 ; Kawaguchi, Atsushi 4 ; Mukae, Hiroshi 5 ; Sakamoto, Noriho 5 ; Ogura, Takashi 6 ; Ikeda, Satoshi 6 ; Kondoh, Yasuhiro 7 ; Yamano, Yasuhiko 7 ; Komiya, Kosaku 8 ; Umeki, Kenji 9 ; Nishikiori, Hirotaka 10 ; Tanino, Yoshinori 11 ; Tsuda, Toru 12 ; Arai, Naoki 13 ; Komatsu, Masamichi 14 ; Sakamoto, Susumu 15 ; Yatera, Kazuhiro 16 ; Inoue, Yoshikazu 17 ; Miyazaki, Yasunari 18 ; Hashimoto, Seishu 19 ; Shimizu, Yasuo 20 ; Hozumi, Hironao 21 ; Ohnishi, Hiroshi 22 ; Handa, Tomohiro 23 ; Hattori, Noboru 24 ; Kishaba, Tomoo 25 ; Kato, Motoyasu 26 ; Inomata, Minoru 27 ; Ishii, Hiroshi 28 ; Hamada, Naoki 29 ; Konno, Satoshi 30 ; Zaizen, Yoshiaki 31 ; Azuma, Arata 32 ; Suda, Takafumi 21 ; Izuhara, Kenji 33 ; Hoshino, Tomoaki 31 

1  Kurume University School of Medicine, Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume, Japan (GRID:grid.410781.b) (ISNI:0000 0001 0706 0776); NHO Kyushu Medical Center, Department of Respirology, Fukuoka, Japan (GRID:grid.415613.4) 
2  Kurume University School of Medicine, Department of Radiology, Kurume, Japan (GRID:grid.410781.b) (ISNI:0000 0001 0706 0776) 
3  Kansai Rosai Hospital, Department of Radiology, Amagasaki, Japan (GRID:grid.414976.9) (ISNI:0000 0004 0546 3696) 
4  Saga Medical School, Education and Research Center for Community Medicine, Faculty of Medicine, Saga, Japan (GRID:grid.412339.e) (ISNI:0000 0001 1172 4459) 
5  Nagasaki University Graduate School of Biomedical Sciences, Department of Respiratory Medicine, Nagasaki, Japan (GRID:grid.174567.6) (ISNI:0000 0000 8902 2273) 
6  Kanagawa Cardiovascular and Respiratory Center, Division of Respiratory Medicine, Yokohama, Kanagawa-ku, Japan (GRID:grid.419708.3) (ISNI:0000 0004 1775 0430) 
7  Tosei General Hospital, Department of Respiratory Medicine and Allergy, Seto, Japan (GRID:grid.417192.8) (ISNI:0000 0004 1772 6756) 
8  Oita University, Respiratory Medicine and Infectious Diseases, Faculty of Medicine, Yufu, Japan (GRID:grid.412334.3) (ISNI:0000 0001 0665 3553) 
9  Tenshindo Hetsugi Hospital, Department of Respiratory Medicine, Oita, Japan (GRID:grid.412334.3) 
10  Sapporo Medical University School of Medicine, Department of Respiratory Medicine and Allergology, Sapporo, Japan (GRID:grid.263171.0) (ISNI:0000 0001 0691 0855) 
11  School of Medicine, Fukushima Medical University, Department of Pulmonary Medicine, Fukushima, Japan (GRID:grid.411582.b) (ISNI:0000 0001 1017 9540) 
12  Kirigaoka Tsuda Hospital, Kitakyushu, Japan (GRID:grid.411582.b) 
13  National Hospital Organization Ibarakihigashi National Hospital, Department of Respiratory Medicine, Tokai-mura, Japan (GRID:grid.505756.4) 
14  Shinshu University School of Medicine, First Department of Internal Medicine, Matsumoto, Japan (GRID:grid.263518.b) (ISNI:0000 0001 1507 4692) 
15  Toho University Omori Medical Center, Department of Respiratory Medicine, Tokyo, Japan (GRID:grid.452874.8) (ISNI:0000 0004 1771 2506) 
16  University of Occupational and Environmental Health, Department of Respiratory Medicine, Kitakyushu, Japan (GRID:grid.271052.3) (ISNI:0000 0004 0374 5913) 
17  National Hospital Organization Kinki-Chuo Chest Medical Center, Clinical Research Center, Sakai, Japan (GRID:grid.415611.6) (ISNI:0000 0004 4674 3774) 
18  Tokyo Medical and Dental University, Department of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Tokyo, Japan (GRID:grid.265073.5) (ISNI:0000 0001 1014 9130) 
19  Tenri Hospital, Department of Respiratory Medicine, Tenri, Japan (GRID:grid.416952.d) (ISNI:0000 0004 0378 4277) 
20  Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Shimotsuga, Japan (GRID:grid.255137.7) (ISNI:0000 0001 0702 8004) 
21  Hamamatsu University School of Medicine, Second Division, Department of Internal Medicine, Hamamatsu, Japan (GRID:grid.505613.4) (ISNI:0000 0000 8937 6696) 
22  Kochi Medical School, Kochi University, Department of Respiratory Medicine and Allergology, Nankoku, Japan (GRID:grid.278276.e) (ISNI:0000 0001 0659 9825) 
23  Graduate School of Medicine, Kyoto University, Department of Advanced Medicine for Respiratory Failure, Sakyo-ku, Japan (GRID:grid.258799.8) (ISNI:0000 0004 0372 2033) 
24  Graduate School of Biomedical Sciences, Hiroshima University, Department of Molecular and Internal Medicine, Minami-ku, Japan (GRID:grid.257022.0) (ISNI:0000 0000 8711 3200) 
25  Okinawa Chubu Hospital, Department of Respiratory Medicine, Uruma, Japan (GRID:grid.416827.e) (ISNI:0000 0000 9413 4421) 
26  Juntendo University Graduate School of Medicine, Department of Respiratory Medicine, Tokyo, Japan (GRID:grid.258269.2) (ISNI:0000 0004 1762 2738) 
27  Japanese Red Cross Medical Center, Department of Respiratory Medicine, Tokyo, Japan (GRID:grid.414929.3) (ISNI:0000 0004 1763 7921) 
28  Fukuoka University Chikushi Hospital, Department of Respiratory Medicine, Chikushino, Japan (GRID:grid.411497.e) (ISNI:0000 0001 0672 2176) 
29  Fukuoka University Hospital, Department of Respiratory Medicine, Fukuoka, Japan (GRID:grid.411556.2) (ISNI:0000 0004 0594 9821) 
30  Faculty of Medicine, Hokkaido University, Department of Respiratory Medicine, Sapporo, Japan (GRID:grid.39158.36) (ISNI:0000 0001 2173 7691) 
31  Kurume University School of Medicine, Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume, Japan (GRID:grid.410781.b) (ISNI:0000 0001 0706 0776) 
32  Mihara General Hospital and Nippon Medical School, Respirology and Clinical Research Center, Tokorozawa, Japan (GRID:grid.410821.e) (ISNI:0000 0001 2173 8328) 
33  Saga Medical School, Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga, Japan (GRID:grid.412339.e) (ISNI:0000 0001 1172 4459) 
Pages
22977
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-023-49180-4
ProQuest document ID
2906651242
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.