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© 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction

Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a rare, highly heterogeneous group of mature T-cell neoplasms that historically has been associated with poor outcomes. We sought to investigate the influence of primary disease site on PTCL-NOS outcomes using a large national cancer registry.

Methods

Baseline clinical and demographic data including primary organ of involvement and Ann Arbor disease stage were extracted from the SEER database. Patients were grouped into nine organ system groups and compared to nodal disease acting as a control. Cox regression models were utilized for adjusted survival analyses.

Results

A total of 3095 patients were identified in the SEER database and included in the final analysis. The median age was 61 and a majority of patients were male (60%) and identified as non-Hispanic white (68%). A plurality of patients had stage IV disease (32%). Lymph nodes and spleen were the most common primary disease sites (67%), while central nervous system was the least common (1%). Patients with early-stage PTCL-NOS of the gastrointestinal/genitourinary systems had worse overall survival [HR = 1.97 (1.50–2.59); p < 0.001] and lymphoma-specific survival [HR = 1.74 (1.26–2.40); p < 0.001] which was statistically significant even after adjusting for other variables. Early-stage PTCL-NOS of the central nervous system also had worse overall survival [HR = 1.90 (1.11–3.27); p = 0.020] and lymphoma-specific survival [HR = 2.11 (1.17–3.80); p = 0.013]. Early-stage PTCL-NOS of the skin had better overall survival [HR = 0.54 (0.42–0.68); p < 0.001] and lymphoma-specific survival [HR = 0.388 (0.28–0.53); p < 0.001] which was statistically significant even after adjustments.

Conclusion

Our findings suggest an association between primary organ involved by PTCL-NOS and both overall and lymphoma-specific survival even after adjusting for common variables. These results warrant validation in future prospective studies.

Details

Title
Impact of primary organ site of involvement by peripheral T-cell lymphoma not otherwise specified on survival
Author
Davis, Olivia 1 ; Truong, Derek 2 ; Day, Silas 3 ; Pandey, Manu 4 ; Ibrahimi, Sami 4 ; Khawandanah, Mohamad 4 ; Holter-Chakrabarty, Jennifer 4 ; Asch, Adam 4 ; Al-Juhaishi, Taha 4   VIAFID ORCID Logo 

 College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA 
 Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA 
 Hematology/Oncology Clinical Trials Office, University of Oklahoma Health Sciences Center – Stephenson Cancer Center, Oklahoma City, Oklahoma, USA 
 Department of Medicine, Section of Hematology and Medical Oncology, University of Oklahoma Health Sciences Center – Stephenson Cancer Center, Oklahoma City, Oklahoma, USA 
Pages
21770-21778
Section
RESEARCH ARTICLES
Publication year
2023
Publication date
Dec 2023
Publisher
John Wiley & Sons, Inc.
e-ISSN
20457634
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2907696583
Copyright
© 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.