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Abstract
The renal angina index (RAI) is a validated scoring tool for predicting acute kidney injury (AKI). We investigated the efficacy of the RAI in 2436 heterogeneous patients (mean age, 70 years) treated in cardiac intensive care units (CICUs). The RAI was calculated from creatinine and patient condition scores. AKI was diagnosed by the Kidney Disease: Improving Global Outcome criteria. The primary and secondary endpoints were the development of severe AKI and all-cause mortality, respectively. Four hundred thirty-three patients developed AKI, 87 of them severe. In multivariate analyses, the RAI was a significant independent predictor of severe AKI. During the 12-month follow-up period, 210 patients suffered all-cause death. Elevated RAI was independently associated with all-cause mortality, as was NT-proBNP (p < 0.001). The RAI is a potent predictor not only of severe AKI but also of adverse outcomes and substantially improved the 12-month risk stratification of patients hospitalized in CICUs.
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Details
1 Fujita Health University School of Medicine, Department of Faculty of Medical Technology, Toyoake, Japan (GRID:grid.256115.4) (ISNI:0000 0004 1761 798X)
2 Fujita Health University School of Medicine, Department of Cardiology, Toyoake, Japan (GRID:grid.256115.4) (ISNI:0000 0004 1761 798X)
3 Fujita Health University School of Medicine, Department of Preventive Medical Sciences, Toyoake, Japan (GRID:grid.256115.4) (ISNI:0000 0004 1761 798X)
4 Okazaki Medical Center, Department of Cardiology, Fujita Health University School of Medicine, Okazaki, Japan (GRID:grid.256115.4) (ISNI:0000 0004 1761 798X)