Abstract

Glioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms underlying this activity are unclear. Here, we reveal a new mechanism used by glioma cells to modulate TMZ sensitivity via regulation of SORBS2 and DDR1 genes by super-enhancer RNA LINC02454. We report that LINC02454 activity increases glioma cell TMZ sensitivity by maintaining long-range chromatin interactions between SORBS2 and the LINC02454 enhancer. By contrast, LINC02454 activity also decreased glioma cell TMZ sensitivity by promoting DDR1 expression. Our study suggests a bivalent function for super-enhancer RNA LINC02454 in regulating glioma cell sensitivity to TMZ.

Details

Title
Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide
Author
Shi, Tengfei 1 ; Guo, Dianhao 2 ; Zheng, Yaoqiang 1 ; Wang, Wenbin 1 ; Bi, Jinfang 3 ; He, Anshun 1 ; Fan, Sibo 1 ; Su, Guangsong 3 ; Zhao, Xueyuan 1 ; Zhao, Zhenhao 1 ; Song, Yingjie 1 ; Sun, Shupeng 4 ; Li, Peng 1 ; Zhao, Zhongfang 1 ; Shi, Jiandang 1 ; Lu, Wange 1   VIAFID ORCID Logo  ; Zhang, Lei 1   VIAFID ORCID Logo 

1  Nankai University, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Tianjin, China (GRID:grid.216938.7) (ISNI:0000 0000 9878 7032) 
2  Shandong First Medical University & Shandong Academy of Medical Sciences, Department of Molecular Biology and Biochemistry, School of Clinical and Basic Medical Sciences, Jinan, China (GRID:grid.410587.f) 
3  Sun Yat-Sen University, Institute of Precision Medicine, The First Affiliated Hospital, Guangzhou, China (GRID:grid.12981.33) (ISNI:0000 0001 2360 039X) 
4  Nankai University, Department of Neurosurgery, Tianjin Huanhu Hospital, School of Medicine, Tianjin, China (GRID:grid.216938.7) (ISNI:0000 0000 9878 7032) 
Pages
6
Publication year
2024
Publication date
Jan 2024
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41419-023-06392-w
ProQuest document ID
2910042469
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.