Abstract

Background

Hemorrhagic shock (HS), which causes insufficient tissue perfusion, can result in multiple organ failure (MOF) and death. This study aimed to evaluate whether doxycycline (DOX) protects cardiovascular, kidney, and liver tissue from damage in a rat model of HS. Immediately before the resuscitation, DOX (10 mg/kg; i.v.) was administered, and its protective effects were assessed 24 h later. Mean arterial pressure, renal blood flow, heart rate, vasoactive drug response, and blood markers such as urea, creatinine, AST, ALT, CPK, CPR, and NOx levels were determined.

Results

We showed that DOX has a significant effect on renal blood flow and on urea, creatinine, AST, ALT, CPK, and NOx. Morphologically, DOX reduced the inflammatory process in the liver tissue.

Conclusions

We conclude that DOX protects the liver and kidney against injury and dysfunction in a HS model and could be a strategy to reduce organ damage associated with ischemia-and-reperfusion injury.

Details

Title
Doxycycline reduces liver and kidney injuries in a rat hemorrhagic shock model
Author
Sordi, Regina 1 ; Bojko, Luana 2 ; Oliveira, Filipe R. M. B. 3 ; Rosales, Thiele Osvaldt 3 ; Souza, Camila Fernandes 3 ; Moreno, Lucas Wenceslau 2 ; Ferreira Alves, Gustavo 3 ; Vellosa, José Carlos Rebuglio 4 ; Fernandes, Daniel 3 ; Gomes, Jose Rosa 5   VIAFID ORCID Logo 

1  Universidade Federal de Santa Catarina, Department of Pharmacology, Graduate Program in Pharmacology, Florianópolis, Brazil (GRID:grid.411237.2) (ISNI:0000 0001 2188 7235); Universidade Estadual de Ponta Grossa, Department of Structural Biology, Molecular and Genetics, Post Graduation Program in Biomedical Science, Ponta Grossa, Brazil (GRID:grid.412323.5) (ISNI:0000 0001 2218 3838) 
2  Universidade Estadual de Ponta Grossa, Department of Structural Biology, Molecular and Genetics, Ponta Grossa, Brazil (GRID:grid.412323.5) (ISNI:0000 0001 2218 3838) 
3  Universidade Federal de Santa Catarina, Department of Pharmacology, Graduate Program in Pharmacology, Florianópolis, Brazil (GRID:grid.411237.2) (ISNI:0000 0001 2188 7235) 
4  Universidade Estadual de Ponta Grossa, Department of Clinical and Toxicological Analysis, Ponta Grossa, Brazil (GRID:grid.412323.5) (ISNI:0000 0001 2218 3838) 
5  Universidade Estadual de Ponta Grossa, Department of Structural Biology, Molecular and Genetics, Post Graduation Program in Biomedical Science, Ponta Grossa, Brazil (GRID:grid.412323.5) (ISNI:0000 0001 2218 3838) 
Pages
2
Publication year
2024
Publication date
Dec 2024
Publisher
Springer Nature B.V.
e-ISSN
2197425X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s40635-023-00586-4
ProQuest document ID
2912140653
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.