Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 3CLpro is a key enzyme in coronavirus proliferation and a treatment target for COVID-19. In vitro and in silico, compounds 1–3 from Glycyrrhiza uralensis had inhibitory activity and binding affinity for 3CLpro. These compounds decreased HCoV-OC43 cytotoxicity in RD cells. Moreover, they inhibited viral growth by reducing the amounts of the necessary proteins (M, N, and RDRP). Therefore, compounds 1–3 are inhibitors of 3CLpro and HCoV-OC43 proliferation.

Details

Title
Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation
Author
Kim, Jang Hoon 1 ; Park, Yea-In 2 ; Mok Hur 1 ; Park, Woo Tae 1 ; Youn-Ho, Moon 1 ; Yun-Chan, Huh 1 ; Tae IL Kim 1 ; Kang, Min Hye 1 ; Kang, Jong Seong 3 ; Cho, Chong Woon 3 ; Park, Junsoo 2 

1  Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung, Republic of Korea 
2  Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea 
3  College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea 
Publication year
2023
Publication date
Dec 2023
Publisher
Taylor & Francis Ltd.
ISSN
14756366
e-ISSN
14756374
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1080/14756366.2023.2242704
ProQuest document ID
2917549048
Copyright
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons  Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.