Abstract

Multiple Sclerosis (MS) is an inflammatory, chronic, autoimmune, and demyelinating disease of the central nervous system. MS is a heterogeneous disease with three main clinical forms, affecting the progression and therefore the treatment of the disease. Thus, finding key genes and microRNAs (miRNA) associated with MS stages and analyzing their interactions is important to better understand the molecular mechanism underlying the occurrence and the evolution of MS. Based on publicly available datasets of mRNA and miRNA expression profiles, differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) between patients with different stages of MS and healthy controls and between relapsing and remitting phases of RRMS were determined using Deseq2 and GEO2R tools. We then analyzed miRNA-mRNA regulatory interactions and gene ontology for the DEGs. Based on miRNA-mRNA regulatory interactions, we identified potential biomarkers of RRMS, 13 upregulated miRNA regulators of 30 downregulated genes and 17 downregulated miRNA regulators of 32 upregulated genes. We also identified 9 downregulated miRNA regulators of 12 upregulated genes as potential biomarkers of SPMS. Our study findings highlight some key protein-coding genes and miRNAs that are involved in the occurrence and evolution of MS.

Competing Interest Statement

The authors have declared no competing interest.

Details

Title
Multiple Sclerosis Stages and their Differentially Expressed Genes: A Bioinformatics Analysis
Author
Alaya, Faten; Baraket, Ghada; Adediran, Daniel A; Cuttler, Katelyn; Ajiboye, Itunu; Kivumbi, Mark T; Sitharam, Nikita; Awe, Olaitan I
University/institution
Cold Spring Harbor Laboratory Press
Section
New Results
Publication year
2024
Publication date
Jan 23, 2024
Publisher
Cold Spring Harbor Laboratory Press
ISSN
2692-8205
Source type
Working Paper
Language of publication
English
ProQuest document ID
2917675648
Copyright
© 2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (“the License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.