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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction: Prevention of tooth loss contributes to an extended life expectancy, namely longevity. Aging-related oral hypofunction, including tooth loss, markedly increases the risks of functional disorder and mortality. Dysbiosis of the oral microbiome has recently been associated with various diseases, such as liver cirrhosis, pancreatic cancer, colorectal cancer, and inflammatory bowel disease. Therefore, the relationship between the oral microbiome and systemic health has been attracting increasing attention. In the present study, we examined oral function and the oral microbiome in the elderly in a world-leading longevity area. Materials and Methods: An oral examination, chewing ability/tongue-lip motor function/saliva tests, and a metagenomic analysis with a 16S rRNA gene-targeting next-generation sequencer were conducted on 78 subjects aged ≥80 years. Twenty-six healthy individuals aged between 20 and 39 years were also investigated as controls. The data obtained were statistically analyzed. The protocol of the present study was approved by the Ethics Review Board of our university (ERB-C-885). Results: Chewing ability, tongue–lip motor function, and saliva volume were normal in elderly subjects with a current tooth number ≥20, but were significantly lower in those with a current tooth number <20. The oral microbiome in elderly subjects with a current tooth number ≥20 and young controls differed from that in elderly subjects with a current tooth number <20. Conclusion: Tooth number ≥20 in elderly subjects in the longevity area contributed to the maintenance of both oral function and the diversity of the oral microbiome.

Details

Title
Oral Function and the Oral Microbiome in the Elderly in the Kyotango Area
Author
Yamamoto, Yoshiaki 1 ; Yamamoto, Toshiro 1   VIAFID ORCID Logo  ; Miyamoto, Nao 1   VIAFID ORCID Logo  ; Kinoshita, Kohei 1 ; Nishikawa, Satomi 1 ; Adachi, Tetsuya 1   VIAFID ORCID Logo  ; Takizawa, Shigeta 1 ; Inoue, Ryo 2   VIAFID ORCID Logo  ; Matoba, Satoaki 3   VIAFID ORCID Logo  ; Kanamura, Narisato 1 

 Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan; [email protected] (Y.Y.); [email protected] (N.M.); [email protected] (K.K.); [email protected] (S.N.); [email protected] (T.A.); [email protected] (S.T.); [email protected] (N.K.) 
 Laboratory of Animal Science, Department of Applied Biological Sciences, Faculty of Agriculture, Setsunan University, Osaka 572-8508, Japan; [email protected] 
 Department of Longevity and Regional Epidemiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan; [email protected] 
First page
16
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
23046767
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2918629164
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.