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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

In this study, the potential use of Artemisia dracunculus essential oil in bio-applications was investigated. Firstly, the phytochemicals from Artemisia dracunculus were analyzed by different methods. Secondly, the Artemisia dracunculus essential oil was incorporated into the hydrogel matrix based on poly(vinyl alcohol) (PVA) and agar (A). The structural, morphological, and physical properties of the hydrogel matrix loaded with different amounts of Artemisia dracunculus essential oil were thoroughly investigated. FTIR analysis revealed the successful loading of the essential oil Artemisia dracunculus into the PVA/A hydrogel matrix. The influence of the mechanical properties and antimicrobial activity of the PVA/A hydrogel matrix loaded with different amounts of Artemisia dracunculus was also assessed. The antimicrobial activity of Artemisia dracunculus (EO Artemisia dracunculus) essential oil was tested using the disk diffusion method and the time-kill assay method after entrapment in the PVA/A hydrogel matrices. The results showed that PVA/agar-based hydrogels loaded with EO Artemisia dracunculus exhibited significant antimicrobial activity (log reduction ratio in the range of 85.5111–100%) against nine pathogenic isolates, both Gram-positive (S. aureus, MRSA, E. faecalis, L. monocytogenes) and Gram-negative (E. coli, K. pneumoniae, S. enteritidis, S. typhimurium, and A. salmonicida). The resulted biocompatible polymers proved to have enhanced properties when functionalized with the essential oil of Artemisia dracunculus, offering opportunities and possibilities for novel applications.

Details

Title
Antimicrobial Activity of Artemisia dracunculus Oil-Loaded Agarose/Poly(Vinyl Alcohol) Hydrogel for Bio-Applications
Author
Rîmbu, Cristina Mihaela 1   VIAFID ORCID Logo  ; Serbezeanu, Diana 2   VIAFID ORCID Logo  ; Vlad-Bubulac, Tăchiță 2   VIAFID ORCID Logo  ; Suflet, Dana Mihaela 2 ; Motrescu, Iuliana 3   VIAFID ORCID Logo  ; Lungoci, Constantin 4   VIAFID ORCID Logo  ; Robu, Teodor 4 ; Vrînceanu, Narcisa 5   VIAFID ORCID Logo  ; Grecu, Mariana 6 ; Andreea Paula Cozma 3 ; Fotea, Lenuța 7 ; Dragoș Constantin Anița 8   VIAFID ORCID Logo  ; Popovici, Ivona 9 ; Horhogea, Cristina Elena 1   VIAFID ORCID Logo 

 Department of Public Health, Iasi “Ion Ionescu de la Brad” University of Life Sciences, 8 Sadoveanu Alley, 707027 Iasi, Romania; [email protected] 
 Department of Polycondensation and Thermally Stable Polymers, “Petru Poni” Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley 41A, 700487 Iasi, Romania; [email protected] (T.V.-B.); [email protected] (D.M.S.) 
 Department of Exact Sciences, Iasi “Ion Ionescu de la Brad” University of Life Sciences, 3 Sadoveanu Alley, 700490 Iasi, Romania; [email protected] (I.M.); [email protected] (A.P.C.) 
 Department of Plant Science, Iasi “Ion Ionescu de la Brad” University of Life Sciences, 3 Sadoveanu Alley, 700490 Iasi, Romania; [email protected] (C.L.); [email protected] (T.R.) 
 Department of Industrial Machines and Equipments, Faculty of Engineering, “Lucian Blaga” University of Sibiu, 10 Victoriei Blvd, 550024 Sibiu, Romania; [email protected] 
 Department of Pharmacology, Iasi “Ion Ionescu de la Brad” University of Life Sciences, 8 Sadoveanu Alley, 707027 Iasi, Romania; [email protected] 
 Department of Animal Resources and Technologies, “Ion Ionescu de la Brad” University of Life Sciences, 700490 Iasi, Romania; [email protected] 
 Regional Center of Advanced Research for Emerging Diseases Zoonoses and Food Safety (ROVETEMERG), “Ion Ionescu de la Brad” University of Life Sciences, 3 Mihail Sadoveanu Alley, 700490 Iasi, Romania; [email protected] 
 Department of Preclinics, Iasi “Ion Ionescu de la Brad” University of Life Sciences, 8 Sadoveanu Alley, 707027 Iasi, Romania; [email protected] 
First page
26
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
23102861
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2918752971
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.