Abstract

An R&D platform for electron FLASH radiation therapy and radiation biology is being prepared at the Photo Injector Test facility at DESY in Zeuthen (FLASHlab@PITZ). This platform is based on the unique beam parameters available at PITZ: ps scale electron bunches of up to 22 MeV with up to 5 nC bunch charge at MHz bunch repetition rate in bunch trains of up to 1 ms in length repeating at 1 to 10 Hz. It works together with the Technical University of Applied Sciences Wildau (TH Wildau) as partner in close vicinity for the biological resources.

A startup beamline has been installed to allow dosimetry studies and irradiation experiments on chemical, biochemical and biological samples after a 60-degree dispersive arm. The measured dose and dose rates under different beam conditions and first experimental results will be reported in this paper. In addition, a dedicated beamline for FLASHlab@PITZhas been designed for better control of the high brightness electron beams. This includes a dogleg to translate the beam and a 2D kicker system to scan the tiny beam focused by quadrupoles across the samples within less than 1 ms. Simulation studies will be presented to demonstrate the extremely flexible dose parameters with various irradiation options for electron FLASH radiation therapy and radiation biology studies.

Details

Title
Overview of FLASHlab@PITZ: the new R&D platform for FLASH radiation therapy and radiation biology
Author
Li, X-K 1 ; Amirkhanyan, Z 1 ; Aftab, N 2 ; Boonpornprasert, P 2 ; Dmytriiev, D 2 ; Frohme, M 3 ; Georgiev, G 2 ; Grebinyk, A 2 ; Gross, M 2 ; Hoffmann, A 2 ; Komar, Y 3 ; Krasilnikov, M 2 ; Loisch, G 4 ; Oppelt, A 2 ; Richard, C 2 ; Riemer, F 2 ; Philipp, S 2 ; Schmitz, M 4 ; Müller, F 2 ; Obier, F 4 ; Vashchenko, G 2 ; Worm, S 2 ; Stephan, F 2 

 on leave from CANDLE Synchrotron Research Institute , Yerevan , Armenia 
 Deutsches Elektronen-Synchrotron DESY , Platanenallee 6, 15738 Zeuthen , Germany 
 Technical University of Applied Sciences Wildau , 15745 Wildau , Germany 
 Deutsches Elektronen-Synchrotron DESY , Notkestr. 85, 22607 Hamburg , Germany 
First page
092006
Publication year
2024
Publication date
Jan 2024
Publisher
IOP Publishing
ISSN
17426588
e-ISSN
17426596
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2918780541
Copyright
Published under licence by IOP Publishing Ltd. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.