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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This is the first study aiming to enrich momilactones A (MA) and B (MB) and phenolic compounds in germinated brown rice (GBR) and non-GBR var. Koshihikari and Milky Queen through the cooking process. Extraction methods for these compounds were optimized by applying various conditions, including solvents (80% methanol and 80% ethanol), heat (80 °C), and sonication (2 h). Momilactone and phenolic quantities were determined by ultra-performance liquid chromatography–electrospray ionization mass spectrometry (UPLC–ESI-MS) and high-performance liquid chromatography (HPLC), respectively. Accordingly, cooked Koshihikari GBR extract using 80% methanol and sonication (GKB4) revealed the highest amounts of tricin, caffeic, ρ-hydroxybenzoic, ρ-coumaric, ferulic, salicylic, and cinnamic acids (1.71, 1.01, 0.62, 0.45, 0.94, 2.50, and 0.37 mg/g DW, respectively), consistent with the strongest antiradical activities in DPPH and ABTS assays (IC50 = 1.47 and 1.70 mg/mL, respectively). Non-cooked GBR Koshihikari extract using 80% ethanol and sonication (GKB9) exhibited the highest MA and MB contents (147.73 and 118.8 μg/g DW, respectively). Notably, GKB9 showed potent inhibition of α-amylase and α-glucosidase (IC50 = 0.48 and 0.15 mg/mL, respectively), compared with the anti-diabetic drug acarbose (IC50 = 0.26 and 2.48 mg/mL, respectively). The findings hold significant implications for developing phenolic- and momilactone-enriched brown rice with health-beneficial properties.

Details

Title
Momilactones and Phenolics in Brown Rice: Enrichment, Optimized Extraction, and Potential for Antioxidant and Anti-Diabetic Activities
Author
Mehedi Hasan 1 ; La Hoang Anh 2   VIAFID ORCID Logo  ; Tran, Dang Xuan 2   VIAFID ORCID Logo 

 Graduate School of Advanced Science and Engineering, Hiroshima University, 1-5-1 Kagamiyama, Higashihiroshima 739-8529, Japan[email protected] (L.H.A.) 
 Graduate School of Advanced Science and Engineering, Hiroshima University, 1-5-1 Kagamiyama, Higashihiroshima 739-8529, Japan[email protected] (L.H.A.); Center for the Planetary Health and Innovation Science (PHIS), The IDEC Institute, Hiroshima University, 1-5-1 Kagamiyama, Higashihiroshima 739-8529, Japan 
First page
6
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
22978739
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2918781814
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.