Abstract
Differentially expressed proteins were screened between VC and normal rats, and the function of differential proteins was classified based on gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. In order to certify the differential proteins, enzyme-linked immunology assay (ELISA) was used to detect the differential proteins in the human seminal plasmas from 30 infertile patients with VC (VC group) and 30 age-matched normal controls (control group) who were recruited from the Department of Reproductive Medicine, Shanxi Provincial People's Hospital from October to December 2019; all participants shared similar demographic characteristics in age, BMI, and endocrine level [Supplementary Table 1, http://links.lww.com/CM9/B733]. According to literature research, two down-regulated proteins of ATPase and Cu2+-transporting alpha (ATP7A) and calcium and integrin-binding protein 1 (CIB1) were screened due to the correlation with spermatogenesis.
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Details
1 Department of Pediatrics, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China
2 Department of Reproductive Genetics, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi 046099, China
3 Department of Biochemistry, Basic Medicine College, Shanxi Medical University, Taiyuan, Shanxi 030607, China
4 Reproductive Medical Department, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China