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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most frequently occurring non-melanocytic skin cancers. The objective of our study is to present the pathophysiology of BCC and cSCC and its direct relationship with the histopathological diagnostics and the differential diagnostics of these types of cancer, based on the morphological characteristics, immunohistochemical profile, and genetic alterations. The qualitative study was based on emphasizing the morphological characteristics and immunohistochemistry profiles of BCC and cSCC and the differential diagnostics based on the tissue samples from the Clinical Pathology Department of Mures Clinical County Hospital between 2020 and 2022. We analyzed the histopathological appearances and immunohistochemical profiles of BCC and cSCC in comparison with those of Bowen disease, keratoacanthoma, hyperkeratotic squamous papilloma, metatypical carcinoma, pilomatricoma, trichoblastoma, Merkel cell carcinoma, pleomorphic dermal sarcoma (PDS), and melanoma. Our study showed the importance of the correct histopathological diagnosis, which has a direct impact on the appropriate treatment and outcome for each patient. The study highlighted the histopathological and morphological characteristics of NMSCs and the precursor lesions in HE and the immunohistochemical profile for lesions that may make the differential diagnosis difficult to establish.

Details

Title
Pathophysiology, Histopathology, and Differential Diagnostics of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma—An Update from the Pathologist’s Point of View
Author
Iuliu Gabriel Cocuz 1   VIAFID ORCID Logo  ; Popelea, Maria Cătălina 2 ; Niculescu, Raluca 1 ; Manea, Andrei 3   VIAFID ORCID Logo  ; Adrian-Horațiu Sabău 1 ; Tinca, Andreea-Cătălina 1   VIAFID ORCID Logo  ; Szoke, Andreea Raluca 1   VIAFID ORCID Logo  ; Budin, Corina Eugenia 4   VIAFID ORCID Logo  ; Stoian, Adina 5   VIAFID ORCID Logo  ; Morariu, Silviu Horia 6 ; Titiana Cornelia Cotoi 7 ; Maria-Elena Cocuz 8   VIAFID ORCID Logo  ; Ovidiu Simion Cotoi 1 

 Pathophysiology Department, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania; [email protected] (I.G.C.); [email protected] (R.N.); [email protected] (A.-H.S.); [email protected] (A.-C.T.); [email protected] (A.R.S.); [email protected] (C.E.B.); [email protected] (A.S.); [email protected] (O.S.C.); Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania 
 Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania 
 Faculty of Medicine, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania; [email protected] 
 Pathophysiology Department, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania; [email protected] (I.G.C.); [email protected] (R.N.); [email protected] (A.-H.S.); [email protected] (A.-C.T.); [email protected] (A.R.S.); [email protected] (C.E.B.); [email protected] (A.S.); [email protected] (O.S.C.); Pneumology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania 
 Pathophysiology Department, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania; [email protected] (I.G.C.); [email protected] (R.N.); [email protected] (A.-H.S.); [email protected] (A.-C.T.); [email protected] (A.R.S.); [email protected] (C.E.B.); [email protected] (A.S.); [email protected] (O.S.C.); Neurology I Clinic, Targu Mures Emergency County Hospital, 540136 Targu Mures, Romania 
 Dermatology Department, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania; [email protected]; Dermatology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania 
 Pharmaceutical Technique Department, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania; [email protected]; Pharmacy No. 2, Mures Clinical County Hospital, 540011 Targu Mures, Romania 
 Fundamental Prophylactic and Clinical Disciplines Department, Faculty of Medicine, Transilvania University of Brasov, 500003 Brașov, Romania; [email protected]; Clinical Pneumology and Infectious Diseases Hospital of Brasov, 500174 Brasov, Romania 
First page
2220
Publication year
2024
Publication date
2024
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2930976010
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.