Conserved neural dynamics and computations across species in olfaction

Abstract

Interpreting chemical information and translating it into ethologically relevant output is a common challenge of olfactory systems across species. Are computations performed by olfactory circuits conserved across species to overcome these common challenges? To investigate this, we compared odor responses in the locust antennal lobe (AL) and mouse olfactory bulb (OB). We found that odors activated nearly mutually exclusive neural ensembles during stimulus presentation (ON response) and after stimulus termination (OFF response). Strikingly, ON and OFF responses evoked by a single odor were anticorrelated with each other. Inverted OFF responses led to a history-dependent suppression of common ensemble elements, which enhanced contrast between odors experienced close together in time. Notably, odor-specific OFF responses persisted long after odor termination in both AL and OB networks. Taken together, our results reveal key neurodynamic features underlying olfactory computations that are conserved across insect and mammalian olfactory systems.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

* New mouse datasets added and analyzed. Additional analyses performed on mouse and locust data. Figures revised to reflect new data and analysis. New supplemental figures 2 and 8. Author Feiyang Deng added. Author affiliations updated.