P1.14 Non-Invasive Assessment of Cardiac Hemodynamic in Copd

Abstract

Introduction

Chronic obstructive pulmonary disease (COPD) is a systemic disease associated with impaired cardiac function. A reduction in stroke volume and cardiac output can be present even with normal ejection fraction in these patients. The non-invasive cardiac output measurement (NICOM) is a simple tool to measure stroke volume (SV) and cardiac output (CO). The aim of this study is to examine the reproducibility of the NICOM in patients with COPD.

Method

The Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE) is a longitudinal study of up to 1500 patients with COPD confirmed with spirometry. Thirty patients with no previous CVD were recruited and underwent height and weight measurements before SV and CO. A bio-reactance technique was used to measure CO and SV. These were repeated after mean (range) 7(1) days.

Results

Mean ±SD age of patients was 67±7 years, height 165±9.9 cm, weight 74.8±18.2 kg and BMI 27.2±4.7 Kg/m2. Mean SV was 83.6±20.6 ml and 81.6± 20.3 ml at visit 1 and 2 and CO was 5.7±1.1 was 5.7± 1.1 L/min respectively. Repeated measures ANOVA showed no significant difference between subject measurements (Both p-values >0.05). The interclass correlation coefficients (ICC’s) were 0.93 and 0.99 respectively. The Bland and Altman plot shows no systematic bias with slight random error in both measures (Figure1 &2)

Conclusion

These data indicate that CO and SV are reproducible measured using the NICOM device in patients with COPD and maybe appropriate to assess cardiac function in clinical practice.