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Introduction
In order to lessen the amount of fluid that is retained in the body, loop diuretics such as Furosemide (FRU) are taken. 4-Chloro-2-[(FRUan-2-ylmethyl) amino] The IUPAC designation for this compound is 5-sulfamoylbenzoic acid. It is acknowledged as a legitimate medication in a variety of pharmacopoeias. There are a variety of generic names for FRU, including Furosemide, Aisemide, Beronald, Desdimin, and Lasilix, amongst others. Conditions such as hypertension, chronic congestive heart failure, and edema caused by hepatic cirrhosis are all able to benefit from the application of FRU 1-2.
Both spirolactone and furosemide are examples of the class of medications known as “diuretics,” which are commonly used to assist the kidneys in excreting excess water from the body. In addition, it prevents hypertension, which is defined as high blood pressure that is brought on by the retention of fluid, and it maintains a healthy potassium balance in the blood 3-4.
Heart failure and ascites due to hepatic diseases are two of the most common indications for the use of spironolactone (SPL; 17-hydroxy-7-mercapto-3-oxo-17-pregen-4-ene-21-carboxylic acid—lactone acetone). It is a diuretic that spares potassium and acts as an antagonist of aldosterone. It is imperative that both medications be taken at the same time in order to mitigate the negative effects of hypokalemia brought on by FRU. A variety of different analytical methods for identifying the presence of both drugs were discovered as a result of the search for relevant literature 5-7. Calculations of FRU were made using a variety of analytical methods, such as spectrophotometry, thin-layer chromatography, spectrofluorimetry, and high-performance liquid chromatography. Furosemide is the first loop diuretic ever developed; hence it is the one that sets the standard. In addition to these side effects, FRU may also cause hyponatremia, hypokalemia, hyperuricaemia, paresthesis, cloudy vision, and orthostatic hypotension 8-10.
Several methods for the determination of Furosemide in bulk, in pharmaceutical samples, and in biological samples 11-12 have been published as a result of this study. In addition to or instead of other medications, these methods can be utilized. In this study, HPTLC strategies were created for the concomitant measurement of FRU and SPL. These methods did not require the use of the solvents that are customarily necessary for chromatographic operations. The development and...