Abstract

Both developed and developing countries carry a large burden of pediatric intussusception. Sentinel site surveillance-based studies have highlighted the difference in the regional incidence of intussusception. The objectives of this manuscript were to geospatially map the locations of hospital-confirmed childhood intussusception cases reported from sentinel hospitals, identify clustering and dispersion, and reveal the potential causes of the underlying pattern. Geospatial analysis revealed positive clustering patterns, i.e., a Moran’s I of 0.071 at a statistically significant (p value < 0.0010) Z score of 16.14 for the intussusception cases across India (cases mapped n = 2221), with 14 hotspots in two states (Kerala = 6 and Tamil Nadu = 8) at the 95% CI. Granular analysis indicated that 67% of the reported cases resided < 50 km from the sentinel hospitals, and the average travel distance to the sentinel hospital from the patient residence was calculated as 47 km (CI 95% min 1 km–max 378 km). Easy access and facility referral preferences were identified as the main causes of the existing clustering pattern of the disease. We recommend designing community-based surveillance studies to improve the understanding of the prevalence and regional epidemiological burden of the disease.

Details

Title
Geospatial methodology for determining the regional prevalence of hospital-reported childhood intussusception in patients from India
Author
Dixit, Shikha 1 ; Das, Manoja Kumar 1 ; Ramadugu, Durga Chitra 1 ; Arora, Narendra Kumar 1 ; Ray, Arindam 2 ; Wakhlu, Ashish 3 ; Vyas, Bhadresh R. 4 ; Bhat, Javeed Iqbal 5 ; Goswami, Jayanta K. 6 ; Mathai, John 7 ; Kameswari, K. 8 ; Bharadia, Lalit 9 ; Sankhe, Lalit 10 ; Ajaya Kumar, M. K. 11 ; Mohan, Neelam 12 ; Jena, Pradeep K. 13 ; Sarangi, Rachita 14 ; Shad, Rashmi 15 ; Debbarma, Sanjib K. 16 ; Shyamala, J. 17 ; Ratan, Simmi K. 18 ; Sarkar, Suman 19 ; Kumar, Vijayendra 20 ; Dubey, Anand P. 21 ; Gupta, Atul 22 ; Tripathy, Bikasha Bihary 23 ; Sam, Cenita J. 24 ; Mufti, Gowhar Nazir 25 ; Trivedi, Harsh 26 ; Shad, Jimmy 17 ; Lahiri, Kaushik 6 ; Luthra, Meera 12 ; Padmalatha, P. 27 ; Kumar, Rakesh 28 ; Sarkar, Ruchirendu 29 ; Kumar, A. Santosh 30 ; Sahoo, Subrat Kumar 31 ; Ghosh, Sunil K. 32 ; Mane, Sushant 33 ; Charoo, Bashir Ahmad 5 ; Prasad, G. Rajendra 8 ; Kumar, S. Harish 17 ; Jothilakshmi, K. 34 ; Sarkar, Nihar Ranjan 35 ; Arunachalam, Pavai 24 ; Mohapatra, Satya S. G. 36 ; Garge, Saurabh 15 

1  The INCLEN Trust International, New Delhi, India (GRID:grid.471013.0) 
2  Bill and Melinda Gates Foundation, India Country Office, New Delhi, India (GRID:grid.471013.0) 
3  King George’s Medical University, Uttar Pradesh, Department of Pediatric Surgery, Lucknow, India (GRID:grid.411275.4) (ISNI:0000 0004 0645 6578) 
4  MP Shah Government Medical College, Department of Pediatrics, Jamnagar, India (GRID:grid.413213.6) 
5  Sher-I-Kashmir Institute of Medical Sciences, Department of Pediatrics, Srinagar, India (GRID:grid.414739.c) (ISNI:0000 0001 0174 2901) 
6  Gauhati Medical College, Department of Pediatric Surgery, Guwahati, India (GRID:grid.411779.d) (ISNI:0000 0001 2109 4622) 
7  PSG Institute of Medical Sciences, Department of Pediatrics, Coimbatore, India (GRID:grid.415349.e) (ISNI:0000 0004 0505 3013); Masonic Medical Centre for Children, Coimbatore, India (GRID:grid.415349.e) 
8  Andhra Medical College, Department of Pediatric Surgery, Vishakhapatnam, India (GRID:grid.419208.6) (ISNI:0000 0004 1767 1767) 
9  Fortis Escorts Hospital, Jaipur, India (GRID:grid.414982.2) (ISNI:0000 0004 1759 6795); Neoclinic Children Hospital, Department of Pediatrics, Jaipur, India (GRID:grid.414982.2) 
10  Grant Medical College and JJ Hospital, Department of Community Medicine, Mumbai, India (GRID:grid.460934.c) (ISNI:0000 0004 1770 5787) 
11  Government Medical College and SAT Hospital, Department of Pediatric Surgery, Thiruvananthapuram, India (GRID:grid.413226.0) (ISNI:0000 0004 1799 9930) 
12  The Medicity, Gurgaon, India (GRID:grid.429252.a) (ISNI:0000 0004 1764 4857) 
13  SCB Medical College, Department of Pediatric Surgery, Cuttack, India (GRID:grid.415328.9) (ISNI:0000 0004 1767 2428) 
14  IMS and SUM Medical College and Hospital, Department of Pediatrics, Bhubaneswar, India (GRID:grid.460934.c) (ISNI:0000 0004 1770 5787) 
15  Choithram Hospital and Research Centre, Indore, India (GRID:grid.414278.c) (ISNI:0000 0004 1800 9070) 
16  Agartala Government Medical College, Department of Pediatrics, Agartala, India (GRID:grid.496568.0) (ISNI:0000 0004 1801 6799) 
17  Apollo Hospitals, Chennai, India (GRID:grid.428010.f) (ISNI:0000 0004 1802 2996) 
18  Maulana Azad Medical College, Department of Pediatric Surgery, Delhi, India (GRID:grid.414698.6) (ISNI:0000 0004 1767 743X) 
19  Institute of Post Graduate Medical Education and Research, Department of Pediatrics, Kolkata, India (GRID:grid.414764.4) (ISNI:0000 0004 0507 4308) 
20  Indira Gandhi Institute of Medical Sciences, Department of Pediatric Surgery, Patna, India (GRID:grid.414608.f) (ISNI:0000 0004 1767 4706) 
21  Maulana Azad Medical College, Department of Pediatrics, Delhi, India (GRID:grid.414698.6) (ISNI:0000 0004 1767 743X) 
22  Fortis Escorts Hospital, Jaipur, India (GRID:grid.414982.2) (ISNI:0000 0004 1759 6795) 
23  IMS and SUM Medical College and Hospital, Department of Pediatric Surgery, Bhubaneswar, India (GRID:grid.460934.c) (ISNI:0000 0004 1770 5787); All India Institute of Medical Sciences, Department of Pediatric Surgery, Bhubaneswar, India (GRID:grid.413618.9) (ISNI:0000 0004 1767 6103) 
24  PSG Institute of Medical Sciences, Department of Pediatric Surgery, Coimbatore, India (GRID:grid.415349.e) (ISNI:0000 0004 0505 3013) 
25  Sher-I-Kashmir Institute of Medical Sciences, Department of Pediatric Surgery, Srinagar, , India (GRID:grid.414739.c) (ISNI:0000 0001 0174 2901) 
26  MP Shah Government Medical College, Department of Pediatric Surgery, Jamnagar, India (GRID:grid.413213.6) 
27  Andhra Medical College, Department of Pediatrics, Vishakhapatnam, India (GRID:grid.419208.6) (ISNI:0000 0004 1767 1767) 
28  Indira Gandhi Institute of Medical Sciences, Department of Pediatrics, Patna, India (GRID:grid.414608.f) (ISNI:0000 0004 1767 4706) 
29  Institute of Postgraduate Medical Education and Research, Department of Pediatric Surgery, Kolkata, India (GRID:grid.414764.4) (ISNI:0000 0004 0507 4308) 
30  Government Medical College and SAT Hospital, Department of Pediatrics, Thiruvananthapuram, India (GRID:grid.413226.0) (ISNI:0000 0004 1799 9930) 
31  IMS and SUM Medical College and Hospital, Department of Pediatric Surgery, Bhubaneswar, India (GRID:grid.460934.c) (ISNI:0000 0004 1770 5787) 
32  Agartala Government Medical College, Department of Pediatric Surgery, Agartala, India (GRID:grid.496568.0) (ISNI:0000 0004 1801 6799) 
33  Grant Medical College and JJ Hospital, Department of Pediatrics, Mumbai, India (GRID:grid.460934.c) (ISNI:0000 0004 1770 5787) 
34  PSG Institute of Medical Sciences, Department of Pediatrics, Coimbatore, India (GRID:grid.415349.e) (ISNI:0000 0004 0505 3013) 
35  Department of Radiology, Institute of Post Graduate Medical Education and Research, Kolkata, India (GRID:grid.414764.4) (ISNI:0000 0004 0507 4308) 
36  IMS and SUM Medical College and Hospital, Department of Radiology, Bhubaneswar, India (GRID:grid.460934.c) (ISNI:0000 0004 1770 5787) 
Pages
6664
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-024-57187-8
ProQuest document ID
2969633195
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.