Abstract

Mental disorders are intricate and multifaceted and encompass social, economic, environmental, and biological factors. This study aimed to explore the potential association between vitamin D deficiency and anxiety and depression symptoms in adults, considering the role of the vitamin D receptor gene polymorphism FokI (rs2228570). This was a population-based cross-sectional study with stratified and cluster sampling, evaluating anxiety symptoms (AS) and depression symptoms (DS) in 1637 adults. Vitamin D levels were measured using electrochemiluminescence and were considered deficient when < 20 ng/mL in a healthy population or < 30 ng/mL in at-risk groups. Genotyping was performed using real-time polymerase chain reaction with TaqMan probes. The prevalence rates of AS, DS, and vitamin D deficiency were 23.5%, 15.8%, and 30.9%, respectively. No direct association was observed between vitamin D deficiency and AS or DS. However, interaction analysis revealed a combined effect of vitamin D deficiency and FokI for DS but not for AS. Individuals with vitamin deficiency and one or two copies of the altered allele of the FokI exhibited a higher prevalence of DS than individuals homozygous for the wild-type allele and vitamin D sufficiency. The interaction between vitamin D deficiency and the FokI polymorphism was associated with DS.

Details

Title
Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based study
Author
da Silva Sabião, Thaís 1   VIAFID ORCID Logo  ; Alves de Menezes-Júnior, Luiz Antônio 1 ; Batista, Aline Priscila 2 ; Silva de Moura, Samara 1 ; Meireles, Adriana Lúcia 3 ; Carvalho de Menezes, Mariana 3 ; Lins Machado-Coelho, George Luiz 4 ; Cardoso Carraro, Júlia Cristina 3 

 Federal University of Ouro Preto, School of Nutrition, Postgraduate Program in Health and Nutrition, Research and Study Group on Nutrition and Public Health (GPENSC), Ouro Preto, Brazil (GRID:grid.411213.4) (ISNI:0000 0004 0488 4317) 
 Federal University of Ouro Preto, Postgraduate Program in Biological Sciences, Ouro Preto, Brazil (GRID:grid.411213.4) (ISNI:0000 0004 0488 4317) 
 Federal University of Ouro Preto, Department of Clinical and Social Nutrition, Research and Study Group on Nutrition and Public Health (GPENSC), School of Nutrition, Ouro Preto, Brazil (GRID:grid.411213.4) (ISNI:0000 0004 0488 4317) 
 Federal University of Ouro Preto, Epidemiology Laboratory, Medical School, Ouro Preto, Brazil (GRID:grid.411213.4) (ISNI:0000 0004 0488 4317) 
Pages
6925
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2973344809
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.