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Copyright © 2024 Laura E. Lavette et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

Myeloid sarcoma (MS) is an extramedullary manifestation of acute myeloid leukemia (AML) and commonly occurs in sites such as the lymph nodes, skin, soft tissues, and bone. It more rarely manifests in the pancreas, with less than 20 cases reported in the literature since 1987. Despite its rarity, MS should be considered in the differential diagnosis of a soft tissue mass causing obstructive jaundice, especially if the patient has a known hematologic disease. Isolated cases of pancreatic MS have been known to progress to AML; therefore, it is crucial to differentiate MS from more common diagnoses, such as pancreatic cancer or pancreatitis. This is a case of a 70-year-old male with symptomatic obstructive jaundice secondary to pancreatic MS, ultimately requiring endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and management. Also included is a comprehensive review of previous case reports with similar clinical presentations, management, and treatment of pancreatic MS.

Details

Title
Pancreatic Myeloid Sarcoma Causing Obstructive Jaundice: A Case Report and Literature Review
Author
Lavette, Laura E 1   VIAFID ORCID Logo  ; Niehaus, Angela G 2 ; Clark, Clancy J 3 ; Conway, Jason D 4 ; Mishra, Girish 4 ; Jahann, Darius A 4   VIAFID ORCID Logo 

 Department of Internal Medicine, University of Virginia Medical Center, 1215 Lee St., Charlottesville, Virginia 22903, USA 
 Department of Pathology, Wake Forest Baptist Health, Medical Center Blvd., Winston-Salem, North Carolina 27157, USA 
 Department of Surgery, Wake Forest Baptist Health, Medical Center Blvd., Winston-Salem, North Carolina 27157, USA 
 Department of Medicine, Section on Gastroenterology and Hepatology, Wake Forest Baptist Health, Medical Center Blvd., Winston-Salem, North Carolina 27157, USA 
Editor
Marcel Cerqueira Cesar Machado
Publication year
2024
Publication date
2024
Publisher
John Wiley & Sons, Inc.
ISSN
20906528
e-ISSN
20906536
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2973764951
Copyright
Copyright © 2024 Laura E. Lavette et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/