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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Preclinical studies have shown that the combination of Cistus × incanus L. and Scutellaria lateriflora L. extracts exerts beneficial effects on oral health against gingivitis. Thus, this study aimed to assess the tolerability of a chewing gum and its efficacy on gingivitis in a double-blind, placebo-controlled clinical trial. Enrolled subjects (n = 60, 18–70 years) were randomized to receive two chewing gums or a placebo daily for 3 months. At baseline (t0) and monthly (t1, t2, and t3) timepoints, the Quantitative Gingival Bleeding Index (QGBI), the Modified Gingival Index (MGI), and the Oral Health 15 items (OH-15)] were employed to assess potential improvements in gingivitis. Pain was self-quantified via the Visual Analogue Scale (VAS), and the Clinical Global Impression Scale for Severity of illness (CGI-S) helped in evaluating the oral general conditions. This study is listed on the ISRCTN registry. At t3, the QGBI, MGI, OH-15, VAS, and CGI-S values decreased in the treated but not in the placebo group (β = 0.6 ± 0.1, t176 = 3.680, p < 0.001; β = 0.87 ± 0.21, t115 = 4.263, p < 0.001; β = 5.3 ± 2.5, t172 = 2.086, p = 0.038; β = 3.16 ± 0.51, t88 = 6.253, p < 0.001; and β = 1.09 ± 0.32, t83 = 3.419, p < 0.001, respectively). A significant improvement in gingival health occurred after a 3-month intervention with the chewing gums containing S. lateriflora and C. incanus extracts.

Details

Title
Efficacy and Tolerability of a Scutellaria lateriflora L. and Cistus × incanus L.-Based Chewing Gum on the Symptoms of Gingivitis: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Author
Alessandro Di Minno 1   VIAFID ORCID Logo  ; Ullah, Hammad 2   VIAFID ORCID Logo  ; De Lellis, Lorenza Francesca 2 ; Buccato, Daniele Giuseppe 2 ; Baldi, Alessandra 2   VIAFID ORCID Logo  ; Cuomo, Paola 3   VIAFID ORCID Logo  ; El-Seedi, Hesham R 4 ; Khalifa, Shaden A M 5 ; Xiao, Xiang 6 ; Piccinocchi, Roberto 7 ; Piccinocchi, Gaetano 8   VIAFID ORCID Logo  ; Sacchi, Roberto 9   VIAFID ORCID Logo  ; Daglia, Maria 10   VIAFID ORCID Logo 

 Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, 80131 Naples, Italy; [email protected] (H.U.); [email protected] (L.F.D.L.); [email protected] (D.G.B.); [email protected] (A.B.); CEINGE-Biotecnologie Avanzate, Via Gaetano Salvatore 486, 80145 Naples, Italy 
 Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, 80131 Naples, Italy; [email protected] (H.U.); [email protected] (L.F.D.L.); [email protected] (D.G.B.); [email protected] (A.B.) 
 Department of Agriculture, University of Naples “Federico II”, Via Università 100, 80055 Naples, Italy; [email protected] 
 Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia; [email protected] 
 Psychiatry and Psychology Department, Capio Saint Göran’s Hospital, Sankt Göransplan 1, 112 19 Stockholm, Sweden; [email protected] 
 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; [email protected] 
 Level 1 Medical Director Anaesthesia and Resuscitation Azienda Universitaria Ospedaliera Vanvitelli, Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 80138 Naples, Italy; [email protected] 
 Comegen Azienda Universitaria Ospedaliera Vanvitelli, Società Cooperativa Sociale di Medici di Medicina Generale, Viale Maria Bakunin 41, 80125 Naples, Italy; [email protected] 
 Applied Statistic Unit, Department of Earth and Environmental Sciences, University of Pavia, Viale Taramelli 24, 27100 Pavia, Italy; [email protected] 
10  Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, 80131 Naples, Italy; [email protected] (H.U.); [email protected] (L.F.D.L.); [email protected] (D.G.B.); [email protected] (A.B.); International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China 
First page
862
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
20726643
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3003350768
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.