Abstract

Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.

Details

Title
Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer
Author
Blanco-Míguez, Aitor 1   VIAFID ORCID Logo  ; Carloni, Sara 2 ; Cardenas, Cindy 3 ; Dioguardi, Carola Conca 4 ; Lambroia, Luca 5   VIAFID ORCID Logo  ; Capretti, Giovanni 6 ; Nappo, Gennaro 6 ; Fugazza, Alessandro 7 ; Capogreco, Antonio 7 ; Armanini, Federica 1 ; Asnicar, Francesco 1   VIAFID ORCID Logo  ; Dubois, Leonard 1 ; Golzato, Davide 1 ; Manghi, Paolo 1   VIAFID ORCID Logo  ; Pinto, Federica 1 ; Scuderi, Cristina 8 ; Casari, Erminia 8 ; Montorsi, Marco 2 ; Anderloni, Andrea 7 ; Rescigno, Maria 2   VIAFID ORCID Logo  ; Repici, Alessandro 9 ; Zerbi, Alessandro 10 ; Peano, Clelia 11 ; Tamburini, Sabrina 12   VIAFID ORCID Logo  ; Rusconi, Roberto 13   VIAFID ORCID Logo  ; Segata, Nicola 14   VIAFID ORCID Logo 

1  University of Trento, Department CIBIO, Trento, Italy (GRID:grid.11696.39) (ISNI:0000 0004 1937 0351) 
2  Humanitas University, Department of Biomedical Sciences, Pieve Emanuele, Italy (GRID:grid.452490.e) (ISNI:0000 0004 4908 9368) 
3  IRCCS Humanitas Research Hospital, Rozzano, Italy (GRID:grid.417728.f) (ISNI:0000 0004 1756 8807) 
4  Rozzano, Institute of Genetics and Biomedical Research, UoS of Milan, National Research Council, Milan, Italy (GRID:grid.5326.2) (ISNI:0000 0001 1940 4177) 
5  University of Brescia, Department of Molecular and Translational Medicine, Brescia, Italy (GRID:grid.7637.5) (ISNI:0000 0004 1757 1846) 
6  IRCCS Humanitas Research Hospital, Department of Pancreatic Surgery, Rozzano, Italy (GRID:grid.417728.f) (ISNI:0000 0004 1756 8807) 
7  IRCCS Humanitas Research Hospital, Department of Gastroenterology, Rozzano, Italy (GRID:grid.417728.f) (ISNI:0000 0004 1756 8807) 
8  IRCCS Humanitas Research Hospital, Microbiology and Virology Unit, Rozzano, Italy (GRID:grid.417728.f) (ISNI:0000 0004 1756 8807) 
9  Humanitas University, Department of Biomedical Sciences, Pieve Emanuele, Italy (GRID:grid.452490.e) (ISNI:0000 0004 4908 9368); IRCCS Humanitas Research Hospital, Department of Gastroenterology, Rozzano, Italy (GRID:grid.417728.f) (ISNI:0000 0004 1756 8807) 
10  Humanitas University, Department of Biomedical Sciences, Pieve Emanuele, Italy (GRID:grid.452490.e) (ISNI:0000 0004 4908 9368); IRCCS Humanitas Research Hospital, Department of Pancreatic Surgery, Rozzano, Italy (GRID:grid.417728.f) (ISNI:0000 0004 1756 8807) 
11  Rozzano, Institute of Genetics and Biomedical Research, UoS of Milan, National Research Council, Milan, Italy (GRID:grid.5326.2) (ISNI:0000 0001 1940 4177); Human Technopole, Milan, Italy (GRID:grid.510779.d) (ISNI:0000 0004 9414 6915) 
12  European Institute of Oncology IRCCS, IEO, Milan, Italy (GRID:grid.15667.33) (ISNI:0000 0004 1757 0843) 
13  Humanitas University, Department of Biomedical Sciences, Pieve Emanuele, Italy (GRID:grid.452490.e) (ISNI:0000 0004 4908 9368); IRCCS Humanitas Research Hospital, Rozzano, Italy (GRID:grid.417728.f) (ISNI:0000 0004 1756 8807) 
14  University of Trento, Department CIBIO, Trento, Italy (GRID:grid.11696.39) (ISNI:0000 0004 1937 0351); European Institute of Oncology IRCCS, IEO, Milan, Italy (GRID:grid.15667.33) (ISNI:0000 0004 1757 0843) 
Pages
35
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20555008
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41522-024-00506-8
ProQuest document ID
3020249736
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.