Ferroptosis: A therapeutic opportunity of inflammatory bowel disease

Abstract

Despite significant progress in IBD treatment in recent years, some patients remain insensitive or non-responsive towards existing treatments. [...]exploring IBD pathogenesis to develop novel therapeutic drugs or drug combinations is quite necessary. [7] Transcription factors and ferroptosis in IBD: [...]several transcription factors, such as nuclear factor erythrocyte 2-related factor 2 (Nrf2), nuclear factor κB (NF-κB), and signal transducer and activator of transcription 3 (STAT3), coordinate susceptibility to ferroptosis through transcription-dependent or non-transcriptional mechanisms [Supplementary Figure 2, http://links.lww.com/CM9/B954]. [1] STAT3 is a crucial transcription factor involved in the response to oxidative stress, and its primary active form is phosphorylated STAT3, which plays a significant role in ferroptosis. Previous studies have demonstrated the significant regulatory role of gut microbial metabolites in cell death [Supplementary Table 2, http://links.lww.com/CM9/B954], including apoptosis, autophagy, pyroptosis, and necroptosis.