To study anti-hyperglycemic actions of three indigenous drugs namely Momordica charantia, Gymnema sylvestre and Piper betle

Abstract

Results: The standard drug, glyburide, significantly reduces hyperglycemia over a period of 2, 4, and 8 h, with maximum effect achieved after 4 h. Therefore, the choice of a diabetic rabbit animal model is authentic and appropriate. Piper betle (family Piperaceae) is such a plant commonly known as "Pan." [...]to explore more about these medicinal plants the present study comprises of anti-hyperglycemic actions of three commonly used indigenous drugs namely M. charanda, G. sylvestre, and P. betle. MATERIALS AND METHODS Animals Healthy albino rabbits of either sex, inbred in the departmental animal house, weighing between 1 and 2 kg, aged between 6 months and 1 year were used for this study. At the beginning of the study, the effect of the three vehicles, i.e. distilled water, 2% Gum Arabic, and 5% tween 80, on FPG were observed in these groups of diabetic rabbits to exclude any significant hypoglycemic effect on their own.