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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Gliomas are a type of brain tumor that requires accurate monitoring for progression following surgery. The Brain Tumor Reporting and Data System (BT-RADS) has emerged as a potential tool for improving diagnostic accuracy and reducing the need for repeated operations. This prospective multicenter study aimed to evaluate the diagnostic accuracy and reliability of BT-RADS in predicting tumor progression (TP) in postoperative glioma patients and evaluate its acceptance in clinical practice. The study enrolled patients with a history of partial or complete resection of high-grade glioma. All patients underwent two consecutive follow-up brain MRI examinations. Five neuroradiologists independently evaluated the MRI examinations using the BT-RADS. The diagnostic accuracy of the BT-RADS for predicting TP was calculated using histopathology after reoperation and clinical and imaging follow-up as reference standards. Reliability based on inter-reader agreement (IRA) was assessed using kappa statistics. Reader acceptance was evaluated using a short survey. The final analysis included 73 patients (male, 67.1%; female, 32.9%; mean age, 43.2 ± 12.9 years; age range, 31–67 years); 47.9% showed TP, and 52.1% showed no TP. According to readers, TP was observed in 25–41.7% of BT-3a, 61.5–88.9% of BT-3b, 75–90.9% of BT-3c, and 91.7–100% of BT-RADS-4. Considering >BT-RADS-3a as a cutoff value for TP, the sensitivity, specificity, and accuracy of the BT-RADS were 68.6–85.7%, 84.2–92.1%, and 78.1–86.3%, respectively, according to the reader. The overall IRA was good (κ = 0.75) for the final BT-RADS classification and very good for detecting new lesions (κ = 0.89). The readers completely agreed with the statement “the application of the BT-RADS should be encouraged” (score = 25). The BT-RADS has good diagnostic accuracy and reliability for predicting TP in postoperative glioma patients. However, BT-RADS 3 needs further improvements to increase its diagnostic accuracy.

Details

Title
Validating Brain Tumor Reporting and Data System (BT-RADS) as a Diagnostic Tool for Glioma Follow-Up after Surgery
Author
Yassir Edrees Almalki 1   VIAFID ORCID Logo  ; Mohammad Abd Alkhalik Basha 2   VIAFID ORCID Logo  ; Maha Ibrahim Metwally 2 ; Nesma Adel Zeed 2 ; Mohamad Gamal Nada 2 ; Sharifa Khalid Alduraibi 3   VIAFID ORCID Logo  ; Morsy, Ahmed A 4   VIAFID ORCID Logo  ; Balata, Rawda 5 ; Al Attar, Ahmed Z 5 ; Amer, Mona M 6 ; Mohamed Abd El-Aziz Mohamed Farag 7 ; Aly, Sameh Abdelaziz 8 ; Abdelkhalik Basha, Ahmed M 9 ; Enas Mahmoud Hamed 2 

 Division of Radiology, Department of Internal Medicine, Medical College, Najran University, Najran 61441, Saudi Arabia; [email protected] 
 Department of Diagnostic Radiology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, Egypt; [email protected] (M.I.M.); [email protected] (N.A.Z.); [email protected] (M.G.N.); [email protected] (E.M.H.) 
 Department of Radiology, College of Medicine, Qassim University, Buraidah 52571, Saudi Arabia; [email protected] 
 Department of Neurosurgery, Faculty of Human Medicine, Zagazig University, Zagazig 44519, Egypt; [email protected] 
 Department of Clinical Oncology and Nuclear Medicine, Faculty of Human Medicine, Zagazig University, Zagazig 44519, Egypt; [email protected] (R.B.); [email protected] (A.Z.A.A.) 
 Department of Neurology, Faculty of Human Medicine, Zagazig University, Zagazig 44519, Egypt; [email protected] 
 Department of Radio-Diagnosis, Faculty of Human Medicine, Al Azhar University, Cairo 11884, Egypt; [email protected] 
 Department of Diagnostic Radiology, Faculty of Human Medicine, Benha University, Benha 13511, Egypt; [email protected] 
 Faculty of General Medicine, Saint Petersburg State University, Egypt Branch, Cairo 11646, Egypt; [email protected] 
First page
887
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
22279059
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3046739381
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.