Full text

Turn on search term navigation

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Featured Application

This work specifically applies to the development and validation of a cardiac simulation model that will facilitate the understanding of and mitigate tricuspid regurgitation (TR). The model employs diagnostic tools and a computational analysis to identify the medical conditions under which TR occurs and assesses the efficacy of potential interventions, notably the Pivot-TR device, in restoring normal heart valve function.

Abstract

Tricuspid regurgitation (TR) resulting from valve abnormalities necessitates precise diagnostic tools and interventions. We employed a simulated heart movement device to examine the performance of heart valve functions and analyzed internal pressure changes to provide a quantitative guide for TR treatment. We developed a simulator capable of replicating the flow profile, mimicking natural heart movements, with sensors installed for measuring internal pressure changes. We conducted an ex vivo experiment on a porcine heart to assess tricuspid valve functionality. An endoscope was installed, with a sensor and endoscopic images to detect abnormalities. TR became evident when the heart rate spectrum exceeded an average of 85.2 bpm (standard deviation, 1.3 bpm) and showed an amplitude higher than an average of 12.3 mmHg (standard deviation, 3.2 mmHg). This critical threshold consistently indicated TR onset. The application of the Pivot-TR attenuated this specific spectral area. We confirmed TR disappearance by reducing the intensity of the Tricuspid Regurgitation Generator or employing the Pivot-TR. The Pivot-TR’s ability to attenuate specific spectral areas associated with TR onset and its effectiveness in restoring normal heart functionality has implications for managing and treating TR, particularly that resulting from age-related structural changes in the heart.

Details

Title
Development of Heart Simulator and Analysis of Valve Dysfunction in Tricuspid Regurgitation
Author
Hwan Yi Joo 1   VIAFID ORCID Logo  ; Ahn, Seokyoung 1   VIAFID ORCID Logo  ; Su-Jin, Jung 2   VIAFID ORCID Logo  ; Min-Ku Chon 3 

 School of Mechanical Engineering, Pusan National University, Busan 46241, Republic of Korea; [email protected] (H.Y.J.); [email protected] (S.A.) 
 Department of Research Strategy Team, R&D Center, TAU MEDICAL Inc., Yangsan 50612, Republic of Korea; [email protected] 
 Department of Internal Medicine, School of Medicine, Pusan National University, Busan 46241, Republic of Korea; Department of Cardiology, Cardiovascular Center, Yangsan Hospital, Yangsan 50612, Republic of Korea 
First page
3307
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
20763417
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3046770631
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.