It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Considering the challenge that cognitive dysfunction and dementia represent to health is imperative to prioritize early diagnosis strategies and explore the pathophysiological mechanisms. There is no consensus on specific markers and physical tests that indicate cognitive decline in older. The objective of this study was to evaluate a panel of inflammatory biomarkers and physical function and investigate their association with cognitive function in community-dwelling older women. Seventy-one participants were included in this study. Cognitive function was assessed by Mini Mental State Examination, muscle strength using dynamometer, body composition using Dual X-ray absorptiometry, respiratory muscle strength using manuvacuometer, and physical function using the Short Physical Performance Battery and Time Up and Go (TUG) tests. Blood samples were collected to analyze a panel of inflammatory biomarkers. The cognitive function was associated with TUG (β = − 0.48; 95%IC = − 0.54 to − 0.21; p < 0.001), inspiratory muscle strength (β = 0.30; 95%IC = 0.005–0.03; p = 0.009), and leptin concentrations (β = 0.32; 95% IC = 0.001–0.006; 0.007). Time spent on TUG test and leptin levels accounted for 27% of variability in cognitive function independent of age. Poorer physical function with leptin plasma levels is associated with decreased cognitive function in older women. These findings contribute to comprehension of pathophysiology underlying cognitive decline and informing the development of new approaches to prevent, diagnose, monitoring and treat cognitive decline in aging.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Universidade Federal dos Vales do Jequitinhonha e Mucuri, Programa de Pós-Graduação em Ciências da Saúde (PPGCS), Diamantina, Brazil (GRID:grid.411287.9) (ISNI:0000 0004 0643 9823); Universidade Federal dos Vales do Jequitinhonha e Mucuri, Departamento de Fisioterapia, Faculdade de Ciências Biológicas e da Saúde, Diamantina, Brazil (GRID:grid.411287.9) (ISNI:0000 0004 0643 9823)
2 Universidade Federal dos Vales do Jequitinhonha e Mucuri, Programa de Pós-Graduação em Reabilitação e Desempenho Funcional (PPGReab), Diamantina, Brazil (GRID:grid.411287.9) (ISNI:0000 0004 0643 9823); Universidade Federal dos Vales do Jequitinhonha e Mucuri, Departamento de Fisioterapia, Faculdade de Ciências Biológicas e da Saúde, Diamantina, Brazil (GRID:grid.411287.9) (ISNI:0000 0004 0643 9823)
3 Universidade Federal dos Vales do Jequitinhonha e Mucuri, Programa de Pós-Graduação em Ciências Fisiológicas (PPGCF), Diamantina, Brazil (GRID:grid.411287.9) (ISNI:0000 0004 0643 9823); Universidade Federal dos Vales do Jequitinhonha e Mucuri, Departamento de Fisioterapia, Faculdade de Ciências Biológicas e da Saúde, Diamantina, Brazil (GRID:grid.411287.9) (ISNI:0000 0004 0643 9823)
4 Universidade Federal de Santa Catarina, Departamento de Fisioterapia, Araranguá, Brazil (GRID:grid.411237.2) (ISNI:0000 0001 2188 7235)
5 Universidade de Brasília, Programa de Pós-Graduação em Educação Física (PPGEF-UnB), Brasília, Brazil (GRID:grid.7632.0) (ISNI:0000 0001 2238 5157)
6 Faculdade de Ciências Médicas de Minas Gerais (FCMMG), Belo Horizonte, Brazil (GRID:grid.419130.e) (ISNI:0000 0004 0413 0953)
7 Universidade Federal dos Vales do Jequitinhonha e Mucuri, Programa de Pós-Graduação em Ciências da Saúde (PPGCS), Diamantina, Brazil (GRID:grid.411287.9) (ISNI:0000 0004 0643 9823); Universidade Federal dos Vales do Jequitinhonha e Mucuri, Programa de Pós-Graduação em Reabilitação e Desempenho Funcional (PPGReab), Diamantina, Brazil (GRID:grid.411287.9) (ISNI:0000 0004 0643 9823); Universidade Federal dos Vales do Jequitinhonha e Mucuri, Departamento de Fisioterapia, Faculdade de Ciências Biológicas e da Saúde, Diamantina, Brazil (GRID:grid.411287.9) (ISNI:0000 0004 0643 9823)