Abstract

HPV vaccination with concomitant HPV-based screening of young women has been proposed for faster cervical cancer elimination. We describe the baseline results of a population-based trial of this strategy to reduce the incidence of HPV. All 89,547 women born 1994-1999 and resident in the capital region of Sweden were personally invited to concomitant HPV vaccination and HPV screening with 26,125 women (29.2%) enrolled between 2021-05-03 and 2022-12-31. Baseline HPV genotyping of cervical samples from the study participants finds, compared to pre-vaccination prevalences, a strong decline of HPV16 and 18 in birth cohorts previously offered vaccination, some decline for cross-protected HPV types but no decline for HPV types not targeted by vaccines. Our dynamic transmission modelling predicts that the trial could reduce the incidence of high-risk HPV infections among the 1994-1998 cohorts by 62-64% in 3 years. Baseline results are prevalences of HPV infection, validated transmission model projections, and power estimates for evaluating HPV incidence reductions at follow-up (+/−0.1% with 99.9% confidence). In conclusion, concomitant HPV vaccination and HPV screening appears to be a realistic option for faster cervical cancer elimination. Clinicaltrials.gov identifier: NCT04910802; EudraCT number: 2020-001169-34.

Here the authors report baseline results of a population-based trial testing concomitant human papillomavirus (HPV) vaccination and HPV-based screening of young women in Sweden and, using a transmission model, suggest that this approach may reduce high-risk HPV infections.

Details

Title
Concomitant human papillomavirus (HPV) vaccination and screening for elimination of HPV and cervical cancer
Author
Arroyo Mühr, Laila Sara 1   VIAFID ORCID Logo  ; Gini, Andrea 2   VIAFID ORCID Logo  ; Yilmaz, Emel 1 ; Hassan, Sadaf S. 1 ; Lagheden, Camilla 1 ; Hultin, Emilie 1   VIAFID ORCID Logo  ; Garcia Serrano, Ainhoa 1   VIAFID ORCID Logo  ; Ure, Agustin E. 1 ; Andersson, Helena 1 ; Merino, Roxana 1   VIAFID ORCID Logo  ; Elfström, K. Miriam 1 ; Baussano, Iacopo 2 ; Dillner, Joakim 1   VIAFID ORCID Logo 

 F56, Center for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626) 
 Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Early Detection, Lyon, France (GRID:grid.17703.32) (ISNI:0000 0004 0598 0095) 
Pages
3679
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3049534995
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.