Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Details

Title
How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?
Author
Willis, Craig R. G. 1 ; Calvaruso, Marco 2 ; Angeloni, Debora 3 ; Baatout, Sarah 4   VIAFID ORCID Logo  ; Benchoua, Alexandra 5 ; Bereiter-Hahn, Juergen 6 ; Bottai, Daniele 7   VIAFID ORCID Logo  ; Buchheim, Judith-Irina 8 ; Carnero-Diaz, Eugénie 9 ; Castiglioni, Sara 10 ; Cavalieri, Duccio 11   VIAFID ORCID Logo  ; Ceccarelli, Gabriele 12 ; Chouker, Alexander 8   VIAFID ORCID Logo  ; Cialdai, Francesca 13 ; Ciofani, Gianni 14   VIAFID ORCID Logo  ; Coppola, Giuseppe 15 ; Cusella, Gabriella 12 ; Degl’Innocenti, Andrea 16 ; Desaphy, Jean-Francois 17   VIAFID ORCID Logo  ; Frippiat, Jean-Pol 18   VIAFID ORCID Logo  ; Gelinsky, Michael 19   VIAFID ORCID Logo  ; Genchi, Giada 14 ; Grano, Maria 17 ; Grimm, Daniela 20   VIAFID ORCID Logo  ; Guignandon, Alain 21 ; Herranz, Raúl 22   VIAFID ORCID Logo  ; Hellweg, Christine 23   VIAFID ORCID Logo  ; Iorio, Carlo Saverio 24   VIAFID ORCID Logo  ; Karapantsios, Thodoris 25   VIAFID ORCID Logo  ; van Loon, Jack 26   VIAFID ORCID Logo  ; Lulli, Matteo 27   VIAFID ORCID Logo  ; Maier, Jeanette 10 ; Malda, Jos 28 ; Mamaca, Emina 29 ; Morbidelli, Lucia 30 ; Osterman, Andreas 31 ; Ovsianikov, Aleksandr 32   VIAFID ORCID Logo  ; Pampaloni, Francesco 33   VIAFID ORCID Logo  ; Pavezlorie, Elizabeth 34 ; Pereda-Campos, Veronica 35 ; Przybyla, Cyrille 36 ; Rettberg, Petra 37   VIAFID ORCID Logo  ; Rizzo, Angela Maria 38   VIAFID ORCID Logo  ; Robson-Brown, Kate 39 ; Rossi, Leonardo 40 ; Russo, Giorgio 2 ; Salvetti, Alessandra 40 ; Risaliti, Chiara 13   VIAFID ORCID Logo  ; Santucci, Daniela 41   VIAFID ORCID Logo  ; Sperl, Matthias 42   VIAFID ORCID Logo  ; Tabury, Kevin 4   VIAFID ORCID Logo  ; Tavella, Sara 43   VIAFID ORCID Logo  ; Thielemann, Christiane 44   VIAFID ORCID Logo  ; Willaert, Ronnie 45   VIAFID ORCID Logo  ; Monici, Monica 13   VIAFID ORCID Logo  ; Szewczyk, Nathaniel J. 46   VIAFID ORCID Logo 

 University of Bradford, School of Chemistry and Biosciences, Faculty of Life Sciences, Bradford, United Kingdom (GRID:grid.6268.a) (ISNI:0000 0004 0379 5283) 
 National Research Council (IBFM-CNR), Institute of Molecular Bioimaging and Physiology, Cefalù, Italy (GRID:grid.428490.3) (ISNI:0000 0004 1789 9809) 
 Scuola Superiore Sant’Anna, Institute of Biorobotics, Pisa, Italy (GRID:grid.263145.7) (ISNI:0000 0004 1762 600X) 
 Belgian Nuclear Research Centre, SCK CEN, Laboratory of Radiobiology, Mol, Belgium (GRID:grid.8953.7) (ISNI:0000 0000 9332 3503) 
 AFM-Téléthon, ISTEM, CECS, Corbeil-Essonnes, France (GRID:grid.453087.d) (ISNI:0000 0000 8578 3614) 
 Institute for Cell and Neurobiol. Goethe University Frankfurt am Main, Frankfurt am Main, Germany (GRID:grid.7839.5) (ISNI:0000 0004 1936 9721) 
 University of Milan, Department of Pharmaceutical Sciences, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822) 
 LMU University Hospital Munich, Laboratory “Translational Research, Stress & Immunity”, Munich, Germany (GRID:grid.411095.8) (ISNI:0000 0004 0477 2585) 
 Sorbonne University, NMNH, CNRS, EPHE, UA, Institute Systematic, Evolution, Biodiversity, Paris, France (GRID:grid.462844.8) (ISNI:0000 0001 2308 1657) 
10  University of Milan, Department of Biomedical and Clinical Sciences, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822) 
11  University of Florence, Department of Biology, Florence, Italy (GRID:grid.8404.8) (ISNI:0000 0004 1757 2304) 
12  University of Pavia, Department of Public Health, Experimental Medicine and Forensic, Pavia, Italy (GRID:grid.8982.b) (ISNI:0000 0004 1762 5736) 
13  ASA Res. Div., DSBSC-University of Florence, ASAcampus Joint Laboratory, Florence, Italy (GRID:grid.8404.8) (ISNI:0000 0004 1757 2304) 
14  Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Pontedera, Italy (GRID:grid.25786.3e) (ISNI:0000 0004 1764 2907) 
15  Institue of Applied Science and Intelligent Sistems – CNR, Naples, Italy (GRID:grid.473542.3) 
16  Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Pontedera, Italy (GRID:grid.25786.3e) (ISNI:0000 0004 1764 2907); University of Siena, Department of Medical Biotechnologies, Siena, Italy (GRID:grid.9024.f) (ISNI:0000 0004 1757 4641) 
17  University of Bari “Aldo Moro”, Department of Precision and Regenerative Medicine, Bari, Italy (GRID:grid.7644.1) (ISNI:0000 0001 0120 3326) 
18  Université de Lorraine, Stress, Immunity, Pathogens Laboratory, SIMPA, Nancy, France (GRID:grid.29172.3f) (ISNI:0000 0001 2194 6418) 
19  Joint & Soft Tissue Research, TU Dresden, Centre for Translational Bone, Dresden, Germany (GRID:grid.4488.0) (ISNI:0000 0001 2111 7257) 
20  Otto-von-Guericke-University Magdeburg, Department of Microgravity and Translational Regenerative Medicine, Magdeburg, Germany (GRID:grid.5807.a) (ISNI:0000 0001 1018 4307); Aarhus University, Department of Biomedicine, Aarhus, Denmark (GRID:grid.7048.b) (ISNI:0000 0001 1956 2722) 
21  Université Jean Monnet, SAINBIOSE, INSERM U1059, Saint-Etienne, France (GRID:grid.6279.a) (ISNI:0000 0001 2158 1682) 
22  Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain (GRID:grid.418281.6) (ISNI:0000 0004 1794 0752) 
23  German Aerospace Center (DLR), Radiation Biology Dept., Inst. of Aerospace Medicine, Cologne, Germany (GRID:grid.7551.6) (ISNI:0000 0000 8983 7915) 
24  Université libre de Bruxelles, CREST-ATM, Brussels, Belgium (GRID:grid.4989.c) (ISNI:0000 0001 2348 6355) 
25  Aristotle Univeristy of Thessaloniki, Faculty of Chemistry, Thessaloniki, Greece (GRID:grid.4793.9) (ISNI:0000 0001 0945 7005) 
26  ACTA/VU, Amsterdam University Medical Center, Amsterdam, Netherlands (GRID:grid.509540.d) (ISNI:0000 0004 6880 3010) 
27  University of Florence, Department of Experimental and Clinical Biomedical Sciences, Florence, Italy (GRID:grid.8404.8) (ISNI:0000 0004 1757 2304) 
28  Univ. Med. Center Utrecht & Dept. Clinical Sciences, Utrecht Univ, Department of Orthopaedics, Utrecht, The Netherlands (GRID:grid.5477.1) (ISNI:0000 0000 9637 0671) 
29  Ifremer centre Bretagne, European and International Affairs Dept, Plouzané, France (GRID:grid.4825.b) (ISNI:0000 0004 0641 9240) 
30  Univ. of Siena, Department of Life Sciences, Siena, Italy (GRID:grid.9024.f) (ISNI:0000 0004 1757 4641) 
31  LMU Munich & DZIF, Partner Site Munich, Max von Pettenkofer Institute, Virology, Munich, Germany (GRID:grid.5252.0) (ISNI:0000 0004 1936 973X) 
32  TU Wien, 3D Printing and Biofabrication, Inst. Materials Science and Technology, Vienna, Austria (GRID:grid.5329.d) (ISNI:0000 0004 1937 0669) 
33  Goethe-Universität Frankfurt am Main, Buchmann Inst. for Molecular Life Sciences, Frankfurt am Main, Germany (GRID:grid.7839.5) (ISNI:0000 0004 1936 9721) 
34  Res. Center in Cooperation with AUVA, Ludwig Boltzmann Inst. for Traumatology, Vienna, Austria (GRID:grid.420022.6) (ISNI:0000 0001 0723 5126) 
35  Université Paul Sabatier Toulouse III, GSBMS/URU EVOLSAN - Medecine Evolutive, Toulouse, France (GRID:grid.15781.3a) (ISNI:0000 0001 0723 035X) 
36  IRD, MARBEC, Univ Montpellier, CNRS, Ifremer, Palavas les Flots, France (GRID:grid.4399.7) (ISNI:0000000122879528) 
37  Research Group Astrobiology, DLR, Institute of Aerospace Medicine, Köln, Germany (GRID:grid.7551.6) (ISNI:0000 0000 8983 7915) 
38  University of Milan, Department of Pharmacological and Biomolecular Sciences, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822) 
39  University of Bristol, Department of Engineering Mathematics, and Dept of Anthropology and Archaeology, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603) 
40  University of Pisa, Department of Clinical and Experimental Medicine, Pisa, Italy (GRID:grid.5395.a) (ISNI:0000 0004 1757 3729) 
41  Ist. Superiore Sanità, Center for Behavioural Sciences and Mental Health, Rome, Italy (GRID:grid.8404.8) 
42  DLR-MP, Cologne, Germany (GRID:grid.8404.8) 
43  DIMES, IRCCS Ospedale Policlinico San Martino and University of Genoa, Genoa, Italy (GRID:grid.5606.5) (ISNI:0000 0001 2151 3065) 
44  University of Applied Sciences Aschaffenburg, BioMEMS Lab, Aschaffenburg, Germany (GRID:grid.465869.0) (ISNI:0000 0001 0411 138X) 
45  Vrije Universiteit Brussels, Research Group NAMI and NANO, Brussels, Belgium (GRID:grid.8767.e) (ISNI:0000 0001 2290 8069) 
46  Ohio University, Heritage College of Osteopathic Medicine, Athens, USA (GRID:grid.20627.31) (ISNI:0000 0001 0668 7841) 
Pages
50
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
23738065
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3049548359
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.