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Abstract
This study evaluated the association of atherogenic index of plasma (AIP) with platelet reactivity and clinical outcomes according to acute myocardial infarction (AMI). The composite of 3-year adverse outcomes of all-cause death, myocardial infarction, and cerebrovascular accident was evaluated in 10,735 patients after successful percutaneous coronary intervention with drug-eluting stents. AIP was defined as the base 10 logarithm of the ratio of triglyceride to high-density lipoprotein cholesterol concentration. High platelet reactivity (HPR) was defined as ≥ 252 P2Y12 reactivity unit. An increase of AIP (per-0.1 unit) was related to the decreased risk of HPR [odds ratio (OR) 0.97, 95% confidence interval (CI) 0.96–0.99; P = 0.001] in non-AMI patients, not in AMI patients (OR 0.98, 95% CI 0.96–1.01; P = 0.138). The HPR was associated with the increased risk of composite outcomes in both non-AMI and AMI patients (all-P < 0.05). AIP levels were not independently associated with the risk of composite outcomes in both patients with non-AMI and AMI. In conclusion, an inverse association between AIP and the risk of HPR was observed in patients with non-AMI. This suggests that the association between plasma atherogenicity and platelet reactivity may play a substantial role in the development of AMI.
Trial registration: NCT04734028.
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1 Chung-Ang University Gwangmyeong Medical Center, Chung-Ang University College of Medicine, Division of Cardiology, Gwangmyeong, South Korea (GRID:grid.254224.7) (ISNI:0000 0001 0789 9563)
2 Chung-Ang University Gwangmyeong Medical Center, Chung-Ang University College of Medicine, Division of Cardiology, Gwangmyeong, South Korea (GRID:grid.254224.7) (ISNI:0000 0001 0789 9563); Busan Veterance Hospital, Division of Cardiology, Busan, South Korea (GRID:grid.254224.7)
3 Kangwon National University School of Medicine, Division of Cardiology, Chuncheon, South Korea (GRID:grid.412010.6) (ISNI:0000 0001 0707 9039)
4 Yonsei University College of Medicine, Division of Cardiology, Severance Cardiovascular Hospital, Seoul, South Korea (GRID:grid.15444.30) (ISNI:0000 0004 0470 5454)
5 Korea University College of Medicine, Division of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, South Korea (GRID:grid.222754.4) (ISNI:0000 0001 0840 2678)
6 Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Division of Cardiology, Changwon, South Korea (GRID:grid.256681.e) (ISNI:0000 0001 0661 1492)
7 Catholic University of Korea, Division of Cardiology, Seoul St. Mary’s Hospital, College of Medicine, Seoul, South Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224)
8 Sungkyunkwan University School of Medicine, Division of Cardiology, Samsung Medical Center, Seoul, South Korea (GRID:grid.264381.a) (ISNI:0000 0001 2181 989X)
9 Yonsei University Wonju Severance Christian Hospital, Division of Cardiology, Wonju, South Korea (GRID:grid.464718.8) (ISNI:0000 0004 0647 3124)
10 Seoul National University Bundang Hospital, Division of Cardiology, Seongnam, South Korea (GRID:grid.412480.b) (ISNI:0000 0004 0647 3378)
11 Hallym University College of Medicine, Division of Cardiology, Kangnam Sacred Heart Hospital, Seoul, South Korea (GRID:grid.256753.0) (ISNI:0000 0004 0470 5964)
12 Seoul National University Hospital, Division of Cardiology, Seoul, South Korea (GRID:grid.412484.f) (ISNI:0000 0001 0302 820X)
13 Dong-A University Hospital, Division of Cardiology, Busan, South Korea (GRID:grid.412048.b) (ISNI:0000 0004 0647 1081)
14 Ulsan University Hospital, University of Ulsan College of Medicine, Division of Cardiology, Ulsan, South Korea (GRID:grid.412830.c) (ISNI:0000 0004 0647 7248)