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Abstract
Repetitive transcranial magnetic stimulation (rTMS) for alleviating negative symptoms and cognitive dysfunction in schizophrenia commonly targets the left dorsolateral prefrontal cortex (LDLPFC). However, the therapeutic effectiveness of rTMS at this site remains inconclusive and increasingly, studies are focusing on cerebellar rTMS. Recently, prolonged intermittent theta-burst stimulation (iTBS) has emerged as a rapid-acting form of rTMS with promising clinical benefits. This study explored the cognitive and neurophysiological effects of prolonged iTBS administered to the LDLPFC and cerebellum in a healthy cohort. 50 healthy participants took part in a cross-over study and received prolonged (1800 pulses) iTBS targeting the LDLPFC, cerebellar vermis, and sham iTBS. Mixed effects repeated measures models examined cognitive and event-related potentials (ERPs) from 2-back (P300, N200) and Stroop (N200, N450) tasks after stimulation. Exploratory non-parametric cluster-based permutation tests compared ERPs between conditions. There were no significant differences between conditions for behavioural and ERP outcomes on the 2-back and Stroop tasks. Exploratory cluster-based permutation tests of ERPs did not identify any significant differences between conditions. We did not find evidence that a single session of prolonged iTBS administered to either the LDLPFC or cerebellum could cause any cognitive or ERP changes compared to sham in a healthy sample.
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Details
1 University of New South Wales, Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, School of Clinical Medicine, Sydney, Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432); Black Dog Institute, Sydney, Australia (GRID:grid.418393.4) (ISNI:0000 0001 0640 7766)
2 University of New South Wales, Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, School of Clinical Medicine, Sydney, Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432)
3 University of New South Wales, Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, School of Clinical Medicine, Sydney, Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432); Black Dog Institute, Sydney, Australia (GRID:grid.418393.4) (ISNI:0000 0001 0640 7766); The George Institute for Global Health, Sydney, Australia (GRID:grid.415508.d) (ISNI:0000 0001 1964 6010)