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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The treatment of chronic wounds involves precise requirements and complex challenges, as the healing process cannot go beyond the inflammatory phase, therefore increasing the healing time and implying a higher risk of opportunistic infection. Following a better understanding of the healing process, oxygen supply has been validated as a therapeutic approach to improve and speed up wound healing. Moreover, the local implications of antimicrobial agents (such as silver-based nano-compounds) significantly support the normal healing process, by combating bacterial contamination and colonization. In this study, silver (S) and tannylated calcium peroxide (CaO2@TA) nanoparticles were obtained by adapted microfluidic and precipitation synthesis methods, respectively. After complementary physicochemical evaluation, both types of nanoparticles were loaded in (Alg) alginate-based gels that were further evaluated as possible dressings for wound healing. The obtained composites showed a porous structure and uniform distribution of nanoparticles through the polymeric matrix (evidenced by spectrophotometric analysis and electron microscopy studies), together with a good swelling capacity. The as-proposed gel dressings exhibited a constant and suitable concentration of released oxygen, as shown for up to eight hours (UV–Vis investigation). The biofilm modulation data indicated a synergistic antimicrobial effect between silver and tannylated calcium peroxide nanoparticles, with a prominent inhibitory action against the Gram-positive bacterial biofilm after 48 h. Beneficial effects in the human keratinocytes cultured in contact with the obtained materials were demonstrated by the performed tests, such as MTT, LDH, and NO.

Details

Title
Infection-Free and Enhanced Wound Healing Potential of Alginate Gels Incorporating Silver and Tannylated Calcium Peroxide Nanoparticles
Author
Bîrcă, Alexandra Catalina 1 ; Gherasim, Oana 2 ; Niculescu, Adelina-Gabriela 3   VIAFID ORCID Logo  ; Alexandru Mihai Grumezescu 3   VIAFID ORCID Logo  ; Vasile, Bogdan Ștefan 4   VIAFID ORCID Logo  ; Mihaiescu, Dan Eduard 5   VIAFID ORCID Logo  ; Ionela, Andreea Neacșu 4   VIAFID ORCID Logo  ; Andronescu, Ecaterina 4   VIAFID ORCID Logo  ; Trușcă, Roxana 4 ; Holban, Alina Maria 6 ; Hudiță, Ariana 7   VIAFID ORCID Logo  ; George-Alexandru Croitoru 8 

 Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania; [email protected] (A.C.B.); [email protected] (A.-G.N.); [email protected] (B.Ș.V.); [email protected] (I.A.N.); [email protected] (E.A.); [email protected] (R.T.); Center for Advanced Research on New Materials, Products and Innovative Processes—CAMPUS Research Institute, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania 
 Lasers Department, National Institute for Laser, Plasma and Radiation Physics, 077125 Magurele, Romania; [email protected] 
 Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania; [email protected] (A.C.B.); [email protected] (A.-G.N.); [email protected] (B.Ș.V.); [email protected] (I.A.N.); [email protected] (E.A.); [email protected] (R.T.); Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania; [email protected] (A.M.H.); [email protected] (A.H.) 
 Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania; [email protected] (A.C.B.); [email protected] (A.-G.N.); [email protected] (B.Ș.V.); [email protected] (I.A.N.); [email protected] (E.A.); [email protected] (R.T.) 
 Department of Organic Chemistry, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania; [email protected] 
 Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania; [email protected] (A.M.H.); [email protected] (A.H.); Department of Microbiology and Immunology, University of Bucharest, 077206 Bucharest, Romania 
 Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania; [email protected] (A.M.H.); [email protected] (A.H.); Department of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania 
 Department II, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474 Bucharest, Romania; [email protected] 
First page
5196
Publication year
2024
Publication date
2024
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3059422170
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.