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Abstract
Adolescent idiopathic scoliosis (AIS) affects approximately 3% of the global population. Recent studies have drawn attention to abnormalities in the dynamics of the CSF as potential contributors. This research aims to employ the Time-Spatial Labeling Inversion Pulse (Time-SLIP) MRI to assess and analyze cerebrospinal fluid (CSF) dynamics in AIS patients. 101 AIS patients underwent Time-SLIP MRI. Images were taken at the mid-cervical and craniocervical junction regions. The sum of the maximum movement distances of CSF on the ventral and dorsal sides of the spinal canal within a single timeframe was defined and measured as Travel Distance (TD). Correlations between TD, age, Cobb angle, and Risser grade were analyzed. TD comparisons were made across Lenke classifications. TD for all patients was a weak correlation with the Cobb angle (r = − 0.16). Comparing TD between Lenke type 1 and 5, type 5 patients display significantly shorter TD (p < 0.05). In Risser5 patients with Lenke type 5 showed a significant negative correlation between Cobb angle and TD (r = − 0.44). Lenke type 5 patients had significantly shorter CSF TD compared to type1, correlating with worsening Cobb angles. Further analysis and exploration are required to understand the mechanism of onset and progression.
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1 Keio University School of Medicine, Department of Orthopaedic Surgery, Tokyo, Japan (GRID:grid.26091.3c) (ISNI:0000 0004 1936 9959)
2 Keio University School of Medicine, Department of Orthopaedic Surgery, Tokyo, Japan (GRID:grid.26091.3c) (ISNI:0000 0004 1936 9959); International University of Health and Welfare, Department of Orthopaedic Surgery, School of Medicine, Chiba, Japan (GRID:grid.411731.1) (ISNI:0000 0004 0531 3030)
3 Keio University School of Medicine, Department of Physiology, Tokyo, Japan (GRID:grid.26091.3c) (ISNI:0000 0004 1936 9959); Central Institute for Experimental Animals, Live Animal Imaging Center, Kanagawa, Japan (GRID:grid.452212.2) (ISNI:0000 0004 0376 978X)