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Abstract
Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) differ in features and outcomes because of variations in embryology, epidemiology, pathology, and prognosis. This study sought to identify significant factors impacting patient survival through Bayesian modelling. Data was retrospectively analysed from a colorectal neoplasia database. Data on demographics, perioperative risks, treatment, mortality, and survival was analysed from patients who underwent colon cancer surgery from January 2010 to December 2021. This study involved 2475 patients, with 58.7% having RCC and 41.3% having LCC. RCC patients had a notably higher mortality rate, and their overall survival (OS) rates were slightly lower than those with LCC (P < 0.05). RCC stages I–IV consistently exhibited worse OS and relapse-free survival (RFS) than LCC (P < 0.05). Factors like age, BMI, ASA score, cancer stage, and comorbidities had significant associations with OS and RFS. Poor and moderate differentiation, lower lymph node yield, and organ resection were linked to lower survival while receiving chemotherapy; higher BMI levels and elective surgery were associated with better survival (all P < 0.05). Our study reveals key differences between RCC and LCC, emphasising the impact of age, BMI, ASA score, cancer stage, and comorbidities on patient survival. These findings could inform personalised treatment strategies for colon cancer patients.
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1 Cabrini Research, Cabrini Hospital, Malvern, Australia (GRID:grid.440111.1) (ISNI:0000 0004 0430 5514); Monash University, School of Public Health and Preventive Medicine, Melbourne, Australia (GRID:grid.1002.3) (ISNI:0000 0004 1936 7857); Monash University, Department of Psychiatry, School of Clinical Sciences, Clayton, Australia (GRID:grid.1002.3) (ISNI:0000 0004 1936 7857)
2 Cabrini Monash University Department of Surgery, Cabrini Hospital, Malvern, Australia (GRID:grid.440111.1) (ISNI:0000 0004 0430 5514); Monash University, Department of Biochemistry and Molecular Biology, Melbourne, Australia (GRID:grid.1002.3) (ISNI:0000 0004 1936 7857)
3 Cabrini Monash University Department of Surgery, Cabrini Hospital, Malvern, Australia (GRID:grid.440111.1) (ISNI:0000 0004 0430 5514)