Abstract

Therapies targeting the PD-1/PD-L1 pathway have transformed head and neck squamous cell carcinoma (HNSCC) treatment. However, predicting the response to anti-PD-1 therapy remains a clinical challenge. This study evaluated the functional binding of PD-1 ligands in 29 HNSCC patients and compared it to the standard PD-L1 Combined Positive Score (CPS). The assessment of PD-1 ligands’ functionality advances the current ability to predict the response of HNSCC patients to anti-PD-1 therapy.

Details

Title
PD1 ligand functionality a biomarker of response to anti PD1 treatment in patients with HNSCC
Author
Kaufman, Bar 1   VIAFID ORCID Logo  ; Taha, Tarek 2   VIAFID ORCID Logo  ; Abramov, Orli 1 ; Zohar, Yaniv 3 ; Mhameed, Kamel 4 ; Cohen, Ofir 1 ; Porgador, Angel 1 ; Elkabets, Moshe 1   VIAFID ORCID Logo  ; Billan, Salem 4 

1  Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Beer-Sheva, Israel (GRID:grid.7489.2) (ISNI:0000 0004 1937 0511) 
2  Israel Institute of Technology-Technion, The Joseph Fishman Oncology Center, Rambam Health Care Campus, Haifa, Affiliated to the Rappaport Faculty of Medicine, Haifa, Israel (GRID:grid.6451.6) (ISNI:0000000121102151); Bar Ilan University, Oncology institute, Tzafon Medical Center, Poriya affiliated with Azrieli Faculty of Medicine, Ramat Gan, Israel (GRID:grid.22098.31) (ISNI:0000 0004 1937 0503) 
3  Rambam Health Care Campus, Institute of Pathology, Haifa, Israel (GRID:grid.413731.3) (ISNI:0000 0000 9950 8111) 
4  Israel Institute of Technology-Technion, The Joseph Fishman Oncology Center, Rambam Health Care Campus, Haifa, Affiliated to the Rappaport Faculty of Medicine, Haifa, Israel (GRID:grid.6451.6) (ISNI:0000000121102151) 
Pages
126
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
ISSN
2397768X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41698-024-00620-y
ProQuest document ID
3063956709
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.