Full text

Turn on search term navigation

© 2005. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

From gamete to neonate, human fertilization is a series of cell motilities (motion and morphological changes). Cytoskeletons play a role in cell motility as they work as a field worker in the cell. The present study is a review of dynamic motility of cytoskeletons (microfilaments and microtubules) during mammalian gamategenesis and fertilization. Dynamic and proper organization of cytoskeletons is crucial for the completion of oocyte maturation and spermatogenesis. By intracytoplasmic sperm injection, some difficulties in fertilization by sperm entry into the egg cytoplasm are overcome. However, the goal of fertilization is the union of the male and female genome, and sperm incorporation into an oocyte is nothing but the beginning of fertilization. Sperm centrosomal function, which introduces microtubule organization and promotes pronuclear apposition and first mitotic spindle formation, plays the leading role in the ‘motility’ of post-intracytoplasmic sperm injection events in fertilization. The present review introduces novel challenges in functional assessment of the human sperm centrosome. Furthermore, microtubule organization during development without the sperm centrosome (e.g. parthenogenesis) is mentioned. (Reprod Med Biol 2005; 4: 179–187)

Details

Title
Cytoskeletal dynamics during mammalian gametegenesis and fertilization: Implications for human reproduction
Author
Terada, Yukihiro 1 ; Morito, Yuki 1 ; Tachibana, Masahito 1 ; Morita, Junko 1 ; NAKAMURA, SO-ICHI 1 ; Murakami, Takashi 1 ; Yaegashi, Nobuo 1 ; Okamura, Kunihiro 1 

 Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Miyagi, Japan 
Section
Gametogenesis
Publication year
2005
Publication date
Sep 2005
Publisher
John Wiley & Sons, Inc.
ISSN
14455781
e-ISSN
14470578
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3066202396
Copyright
© 2005. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.