Abstract

Future multi-year crewed planetary missions will motivate advances in aerospace nutrition and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in the human body. Here, we propose that a parallel Human Cell Space Atlas could serve as an openly available, global resource for space life science research. As humanity becomes increasingly spacefaring, high-resolution omics on orbit could permit an advent of precision spaceflight healthcare. Alongside the scientific potential, we consider the complex ethical, cultural, and legal challenges intrinsic to the human space omics discipline, and how philosophical frameworks may benefit from international perspectives.

High-resolution omics data have facilitated the ongoing Human Cell Atlas project. In this Perspective, Rutter and colleagues propose that a parallel Human Cell Space Atlas initiative would provide a platform for spaceflight-associated research and healthcare.

Details

Title
Astronaut omics and the impact of space on the human body at scale
Author
Rutter, Lindsay A. 1 ; Cope, Henry 2   VIAFID ORCID Logo  ; MacKay, Matthew J. 3 ; Herranz, Raúl 4   VIAFID ORCID Logo  ; Das, Saswati 5 ; Ponomarev, Sergey A. 6   VIAFID ORCID Logo  ; Costes, Sylvain V. 7   VIAFID ORCID Logo  ; Paul, Amber M. 8 ; Barker, Richard 9 ; Taylor, Deanne M. 10   VIAFID ORCID Logo  ; Bezdan, Daniela 11   VIAFID ORCID Logo  ; Szewczyk, Nathaniel J. 12   VIAFID ORCID Logo  ; Muratani, Masafumi 13   VIAFID ORCID Logo  ; Mason, Christopher E. 14   VIAFID ORCID Logo  ; Giacomello, Stefania 15   VIAFID ORCID Logo 

1  University of Tsukuba, Transborder Medical Research Center, Tsukuba, Japan (GRID:grid.20515.33) (ISNI:0000 0001 2369 4728); University of Tsukuba, Department of Genome Biology, Institute of Medicine, Tsukuba, Japan (GRID:grid.20515.33) (ISNI:0000 0001 2369 4728); University of Glasgow, School of Chemistry, Glasgow, UK (GRID:grid.8756.c) (ISNI:0000 0001 2193 314X) 
2  University of Nottingham, School of Medicine, Derby, UK (GRID:grid.4563.4) (ISNI:0000 0004 1936 8868) 
3  Weill Cornell Medicine, Department of Physiology and Biophysics, New York, USA (GRID:grid.471410.7) (ISNI:0000 0001 2179 7643); Weill Cornell Medicine, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, USA (GRID:grid.471410.7) (ISNI:0000 0001 2179 7643); Weill Cornell Medicine, The WorldQuant Initiative for Quantitative Prediction, New York, USA (GRID:grid.471410.7) (ISNI:0000 0001 2179 7643) 
4  Centro de Investigaciones Biológicas “Margarita Salas” (CSIC), Madrid, Spain (GRID:grid.418281.6) (ISNI:0000 0004 1794 0752) 
5  Atal Bihari Vajpayee Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital, Department of Biochemistry, New Delhi, India (GRID:grid.414117.6) (ISNI:0000 0004 1767 6509) 
6  Russian Academy of Sciences, Department of Immunology and Microbiology, Institute for the Biomedical Problems, Moscow, Russia (GRID:grid.4886.2) (ISNI:0000 0001 2192 9124) 
7  NASA Ames Research Center, Space Biosciences Division, Moffett Field, USA (GRID:grid.419075.e) (ISNI:0000 0001 1955 7990) 
8  Department of Human Factors and Behavioral Neurobiology, Embry-Riddle Aeronautical University, Daytona Beach, USA (GRID:grid.255501.6) (ISNI:0000 0001 0561 4552) 
9  University of Wisconsin-Madison, Department of Botany, Madison, USA (GRID:grid.14003.36) (ISNI:0000 0001 2167 3675) 
10  The Children’s Hospital of Philadelphia, Department of Biomedical and Health Informatics, Philadelphia, USA (GRID:grid.239552.a) (ISNI:0000 0001 0680 8770); University of Pennsylvania, Department of Pediatrics, Perelman School of Medicine, Philadelphia, USA (GRID:grid.25879.31) (ISNI:0000 0004 1936 8972) 
11  University of Tübingen, Institute of Medical Genetics and Applied Genomics, Tübingen, Germany (GRID:grid.10392.39) (ISNI:0000 0001 2190 1447); University of Tübingen, NGS Competence Center Tübingen (NCCT), Tübingen, Germany (GRID:grid.10392.39) (ISNI:0000 0001 2190 1447); yuri GmbH, Meckenbeuren, Germany (GRID:grid.10392.39) 
12  University of Nottingham, School of Medicine, Derby, UK (GRID:grid.4563.4) (ISNI:0000 0004 1936 8868); Ohio University, Ohio Musculoskeletal and Neurological Institute (OMNI), Heritage College of Osteopathic Medicine, Athens, USA (GRID:grid.20627.31) (ISNI:0000 0001 0668 7841) 
13  University of Tsukuba, Transborder Medical Research Center, Tsukuba, Japan (GRID:grid.20515.33) (ISNI:0000 0001 2369 4728); University of Tsukuba, Department of Genome Biology, Institute of Medicine, Tsukuba, Japan (GRID:grid.20515.33) (ISNI:0000 0001 2369 4728) 
14  Weill Cornell Medicine, Department of Physiology and Biophysics, New York, USA (GRID:grid.471410.7) (ISNI:0000 0001 2179 7643); Weill Cornell Medicine, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, USA (GRID:grid.471410.7) (ISNI:0000 0001 2179 7643); Weill Cornell Medicine, The WorldQuant Initiative for Quantitative Prediction, New York, USA (GRID:grid.471410.7) (ISNI:0000 0001 2179 7643); Weill Cornell Medicine, The Feil Family Brain and Mind Research Institute, New York, USA (GRID:grid.471410.7) (ISNI:0000 0001 2179 7643) 
15  KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden (GRID:grid.5037.1) (ISNI:0000000121581746) 
Pages
4952
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-024-47237-0
ProQuest document ID
3066599187
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.