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© 2024. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background:Schizophrenia is a complex mental disorder characterized by significant cognitive and neurobiological alterations. Impairments in cognitive function and eye movement have been known to be promising biomarkers for schizophrenia. However, cognitive assessment methods require specialized expertise. To date, data on simplified measurement tools for assessing both cognitive function and eye movement in patients with schizophrenia are lacking.

Objective:This study aims to assess the efficacy of a novel tablet-based platform combining cognitive and eye movement measures for classifying schizophrenia.

Methods:Forty-four patients with schizophrenia, 67 healthy controls, and 41 patients with other psychiatric diagnoses participated in this study from 10 sites across Japan. A free-viewing eye movement task and 2 cognitive assessment tools (Codebreaker task from the THINC-integrated tool and the CognitiveFunctionTest app) were used for conducting assessments in a 12.9-inch iPad Pro. We performed comparative group and logistic regression analyses for evaluating the diagnostic efficacy of the 3 measures of interest.

Results:Cognitive and eye movement measures differed significantly between patients with schizophrenia and healthy controls (all 3 measures; P<.001). The Codebreaker task showed the highest classification effectiveness in distinguishing schizophrenia with an area under the receiver operating characteristic curve of 0.90. Combining cognitive and eye movement measures further improved accuracy with a maximum area under the receiver operating characteristic curve of 0.94. Cognitive measures were more effective in differentiating patients with schizophrenia from healthy controls, whereas eye movement measures better differentiated schizophrenia from other psychiatric conditions.

Conclusions:This multisite study demonstrates the feasibility and effectiveness of a tablet-based app for assessing cognitive functioning and eye movements in patients with schizophrenia. Our results suggest the potential of tablet-based assessments of cognitive function and eye movement as simple and accessible evaluation tools, which may be useful for future clinical implementation.

Details

Title
Tablet-Based Cognitive and Eye Movement Measures as Accessible Tools for Schizophrenia Assessment: Multisite Usability Study
Author
Morita, Kentaro  VIAFID ORCID Logo  ; Miura, Kenichiro  VIAFID ORCID Logo  ; Toyomaki, Atsuhito  VIAFID ORCID Logo  ; Makinodan, Manabu  VIAFID ORCID Logo  ; Ohi, Kazutaka  VIAFID ORCID Logo  ; Hashimoto, Naoki  VIAFID ORCID Logo  ; Yasuda, Yuka  VIAFID ORCID Logo  ; Mitsudo, Takako  VIAFID ORCID Logo  ; Higuchi, Fumihiro  VIAFID ORCID Logo  ; Numata, Shusuke  VIAFID ORCID Logo  ; Yamada, Akiko  VIAFID ORCID Logo  ; Aoki, Yohei  VIAFID ORCID Logo  ; Honda, Hiromitsu  VIAFID ORCID Logo  ; Mizui, Ryo  VIAFID ORCID Logo  ; Honda, Masato  VIAFID ORCID Logo  ; Fujikane, Daisuke  VIAFID ORCID Logo  ; Matsumoto, Junya  VIAFID ORCID Logo  ; Hasegawa, Naomi  VIAFID ORCID Logo  ; Ito, Satsuki  VIAFID ORCID Logo  ; Akiyama, Hisashi  VIAFID ORCID Logo  ; Onitsuka, Toshiaki  VIAFID ORCID Logo  ; Satomura, Yoshihiro  VIAFID ORCID Logo  ; Kasai, Kiyoto  VIAFID ORCID Logo  ; Hashimoto, Ryota  VIAFID ORCID Logo 
First page
e56668
Section
Diagnostic Tools in Mental Health
Publication year
2024
Publication date
2024
Publisher
JMIR Publications
e-ISSN
23687959
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3066835119
Copyright
© 2024. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.