Abstract

The relationship between blood group and rebleeding in acute lower gastrointestinal bleeding (ALGIB) remains unclear. This study aimed to investigate the association between blood group O and clinical outcomes in patients with ALGIB. The study included 2336 patients with ALGIB whose bleeding source was identified during initial endoscopy (from the CODE BLUE-J Study). The assessed outcomes encompassed rebleeding and other clinical parameters. The rebleeding rates within 30 days in patients with blood group O and those without blood group O were 17.9% and 14.9%, respectively. Similarly, the rates within 1 year were 21.9% for patients with blood group O and 18.2% for those without blood group O. In a multivariate analysis using age, sex, vital signs at presentation, blood test findings, comorbidities, antithrombotic medication, active bleeding, and type of endoscopic treatment as covariates, patients with blood group O exhibited significantly higher risks for rebleeding within 30 days (odds ratio [OR] 1.31; 95% confidence interval [CI] 1.04–1.65; P = 0.024) and 1 year (OR 1.29; 95% CI 1.04–1.61; P = 0.020) compared to those without blood group O. However, the thrombosis and mortality rates did not differ significantly between blood group O and non-O patients. In patients with ALGIB, blood group O has been identified as an independent risk factor for both short- and long-term rebleeding.

Details

Title
Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study
Author
Suzuki, Sho 1 ; Tominaga, Naoyuki 2 ; Aoki, Tomonori 3 ; Sadashima, Eiji 4 ; Miike, Tadashi 1 ; Kawakami, Hiroshi 1 ; Kobayashi, Katsumasa 5 ; Yamauchi, Atsushi 6 ; Yamada, Atsuo 3 ; Omori, Jun 7 ; Ikeya, Takashi 8 ; Aoyama, Taiki 9 ; Sato, Yoshinori 10 ; Kishino, Takaaki 11 ; Ishii, Naoki 12 ; Sawada, Tsunaki 13 ; Murata, Masaki 14 ; Takao, Akinari 15 ; Mizukami, Kazuhiro 16 ; Kinjo, Ken 17 ; Fujimori, Shunji 18 ; Uotani, Takahiro 19 ; Fujita, Minoru 20 ; Sato, Hiroki 21 ; Narasaka, Toshiaki 22 ; Hayasaka, Junnosuke 23 ; Funabiki, Tomohiro 24 ; Kinjo, Yuzuru 25 ; Mizuki, Akira 26 ; Kiyotoki, Shu 27 ; Mikami, Tatsuya 28 ; Gushima, Ryosuke 29 ; Fujii, Hiroyuki 30 ; Fuyuno, Yuta 31 ; Hikichi, Takuto 32 ; Toya, Yosuke 33 ; Narimatsu, Kazuyuki 34 ; Manabe, Noriaki 35 ; Nagaike, Koji 36 ; Kinjo, Tetsu 37 ; Sumida, Yorinobu 38 ; Funakoshi, Sadahiro 39 ; Kobayashi, Kiyonori 40 ; Matsuhashi, Tamotsu 41 ; Komaki, Yuga 42 ; Kaise, Mitsuru 7 ; Nagata, Naoyoshi 43 

 University of Miyazaki Hospital, Department of Gastroenterology and Hepatology, Center for Digestive Disease and Division of Endoscopy, Miyazaki, Japan (GRID:grid.416001.2) (ISNI:0000 0004 0596 7181) 
 Saga-Ken Medical Centre Koseikan, Department of Gastroenterology, Saga, Japan (GRID:grid.416533.6) 
 The University of Tokyo, Department of Gastroenterology, Graduate School of Medicine, Tokyo, Japan (GRID:grid.26999.3d) (ISNI:0000 0001 2169 1048) 
 Saga-Ken Medical Centre Koseikan, Department of Medical Research Institute, Saga, Japan (GRID:grid.416533.6) 
 Tokyo Metropolitan Bokutoh Hospital, Department of Gastroenterology, Tokyo, Japan (GRID:grid.414532.5) (ISNI:0000 0004 1764 8129) 
 Tazuke Kofukai Medical Research Institute, Department of Gastroenterology and Hepatology, Kitano Hospital, Osaka, Japan (GRID:grid.415392.8) (ISNI:0000 0004 0378 7849) 
 Nippon Medical School, Graduate School of Medicine, Department of Gastroenterology, Tokyo, Japan (GRID:grid.410821.e) (ISNI:0000 0001 2173 8328) 
 St Luke’s International University, Department of Gastroenterology, Tokyo, Japan (GRID:grid.419588.9) (ISNI:0000 0001 0318 6320) 
 Hiroshima City Asa Citizens Hospital, Department of Gastroenterology, Hiroshima, Japan (GRID:grid.414157.2) (ISNI:0000 0004 0377 7325) 
10  St Marianna University School of Medicine, Division of Gastroenterology, Department of Internal Medicine, Kanagawa, Japan (GRID:grid.412764.2) (ISNI:0000 0004 0372 3116) 
11  Nara City Hospital, Department of Gastroenterology and Hepatology, Center for Digestive and Liver Diseases, Nara, Japan (GRID:grid.416484.b) (ISNI:0000 0004 0647 5533) 
12  Tokyo Shinagawa Hospital, Department of Gastroenterology, Tokyo, Japan (GRID:grid.416484.b) 
13  Nagoya University Hospital, Department of Endoscopy, Aichi, Japan (GRID:grid.437848.4) (ISNI:0000 0004 0569 8970) 
14  National Hospital Organization Kyoto Medical Center, Department of Gastroenterology, Kyoto, Japan (GRID:grid.410835.b) 
15  Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Department of Gastroenterology, Tokyo, Japan (GRID:grid.415479.a) (ISNI:0000 0001 0561 8609) 
16  Oita University, Department of Gastroenterology, Oita, Japan (GRID:grid.412334.3) (ISNI:0000 0001 0665 3553) 
17  Fukuoka University Chikushi Hospital, Department of Gastroenterology, Fukuoka, Japan (GRID:grid.411497.e) (ISNI:0000 0001 0672 2176) 
18  Chiba Hokusoh Hospital, Nippon Medical School, Department of Gastroenterology, Chiba, Japan (GRID:grid.410821.e) (ISNI:0000 0001 2173 8328) 
19  Japanese Red Cross Shizuoka Hospital, Department of Gastroenterology, Shizuoka, Japan (GRID:grid.410790.b) (ISNI:0000 0004 0604 5883) 
20  Kawasaki Medical School General Medical Center, Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Okayama, Japan (GRID:grid.415086.e) (ISNI:0000 0001 1014 2000) 
21  Niigata University, Division of Gastroenterology, Graduate School of Medical and Dental Sciences, Niigata, Japan (GRID:grid.260975.f) (ISNI:0000 0001 0671 5144) 
22  University of Tsukuba, Department of Gastroenterology, Ibaraki, Japan (GRID:grid.20515.33) (ISNI:0000 0001 2369 4728); University of Tsukuba Hospital, Division of Endoscopic Center, Ibaraki, Japan (GRID:grid.412814.a) (ISNI:0000 0004 0619 0044) 
23  Toranomon Hospital, Department of Gastroenterology, Tokyo, Japan (GRID:grid.410813.f) (ISNI:0000 0004 1764 6940) 
24  Fujita Health University Hospital, Department of Emergency Medicine, Aichi, Japan (GRID:grid.471500.7) (ISNI:0000 0004 0649 1576); Saiseikai Yokohama Tobu Hospital, Emergency and Critical Care Center, Kanagawa, Japan (GRID:grid.471500.7) 
25  Naha City Hospital, Department of Gastroenterology, Okinawa, Japan (GRID:grid.474837.b) (ISNI:0000 0004 1772 2157) 
26  Tokyo Saiseikai Central Hospital, Department of Internal Medicine, Tokyo, Japan (GRID:grid.270560.6) (ISNI:0000 0000 9225 8957) 
27  Shuto General Hospital, Department of Gastroenterology, Yamaguchi, Japan (GRID:grid.415872.d) (ISNI:0000 0004 1781 5521) 
28  Hirosaki University Hospital, Division of Endoscopy, Hirosaki, Japan (GRID:grid.470096.c) 
29  Kumamoto University, Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto, Japan (GRID:grid.274841.c) (ISNI:0000 0001 0660 6749) 
30  National Hospital Organization Fukuokahigashi Medical Center, Department of Gastroenterology and Hepatology, Fukuoka, Japan (GRID:grid.416698.4) 
31  Kyushu University, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Fukuoka, Japan (GRID:grid.177174.3) (ISNI:0000 0001 2242 4849) 
32  Fukushima Medical University Hospital, Department of Endoscopy, Fukushima, Japan (GRID:grid.471467.7) (ISNI:0000 0004 0449 2946) 
33  Iwate Medical University, Division of Gastroenterology, Department of Internal Medicine, Iwate, Japan (GRID:grid.411790.a) (ISNI:0000 0000 9613 6383) 
34  National Defense Medical College, Department of Internal Medicine, Saitama, Japan (GRID:grid.416614.0) (ISNI:0000 0004 0374 0880) 
35  Kawasaki Medical School, Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kurashiki, Japan (GRID:grid.415086.e) (ISNI:0000 0001 1014 2000) 
36  Suita Municipal Hospital, Department of Gastroenterology and Hepatology, Osaka, Japan (GRID:grid.416694.8) (ISNI:0000 0004 1772 1154) 
37  University of the Ryukyus Hospital, Department of Endoscopy, Okinawa, Japan (GRID:grid.267625.2) (ISNI:0000 0001 0685 5104) 
38  National Hospital Organization Kyushu Medical Center, Department of Gastroenterology, Fukuoka, Japan (GRID:grid.415613.4) 
39  Fukuoka University Hospital, Department of Gastroenterological Endoscopy, Fukuoka, Japan (GRID:grid.411556.2) (ISNI:0000 0004 0594 9821) 
40  Kitasato University, School of Medicine, Department of Gastroenterology, Kanagawa, Japan (GRID:grid.410786.c) (ISNI:0000 0000 9206 2938) 
41  Akita University Graduate School of Medicine, Department of Gastroenterology and Neurology, Akita, Japan (GRID:grid.251924.9) (ISNI:0000 0001 0725 8504) 
42  Kagoshima University Graduate School of Medical and Dental Sciences, Digestive and Lifestyle Diseases, and Hygiene and Health Promotion Medicine, Kagoshima, Japan (GRID:grid.258333.c) (ISNI:0000 0001 1167 1801) 
43  Tokyo Medical University, Department of Gastroenterological Endoscopy, Tokyo, Japan (GRID:grid.410793.8) (ISNI:0000 0001 0663 3325); National Center for Global Health and Medicine, Department of Gastroenterology and Hepatology, Tokyo, Japan (GRID:grid.45203.30) (ISNI:0000 0004 0489 0290) 
Pages
13983
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3068991384
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.