Abstract

Drug exposure during pregnancy lacks global fetal safety data. The maternal drug exposure birth cohort (DEBC) study, a prospective longitudinal investigation, aims to explore the correlation of maternal drug exposure during pregnancy with pregnancy outcomes, and establish a human biospecimen biobank. Here we describe the process of establishing DEBC and show that the drug exposure rate in the first trimester of pregnant women in DEBC (n = 112,986) is 30.70%. Among the drugs used, dydrogesterone and progesterone have the highest exposure rates, which are 11.97% and 10.82%, respectively. The overall incidence of adverse pregnancy outcomes is 13.49%. Dydrogesterone exposure during the first trimester is correlated with higher incidences of stillbirth, preterm birth, low birth weight, and birth defects, along with a lower incidence of miscarriage/abortion. Due to the limitations of this cohort study, causative conclusions cannot be drawn. Further follow-up and in-depth data analysis are planned for future studies.

Drug exposure during pregnancy lacks sufficient fetal safety information world-widely. Here, the authors report the establishment a multi-center birth cohort to explore the correlation of maternal drug exposure during pregnancy with pregnancy outcomes.

Details

Title
The maternal drug exposure birth cohort (DEBC) in China
Author
Li, Lu 1 ; Wang, Ke 1 ; Wang, Meixian 1 ; Tao, Jing 2 ; Li, Xiaohong 2 ; Liu, Zhen 2 ; Li, Nana 2 ; Qiu, Xiaoxia 3 ; Wei, Hongwei 3 ; Lin, Yuan 4 ; He, Yuan 5 ; Deng, Ying 2 ; Kang, Hong 2 ; Li, Yuting 2 ; Yu, Ping 1   VIAFID ORCID Logo  ; Wang, Yanping 1 ; Zhu, Jun 1   VIAFID ORCID Logo  ; Liu, Hanmin 6 

 Sichuan University, National Center for Birth Defect Monitoring, West China Second University Hospital, Chengdu, China (GRID:grid.13291.38) (ISNI:0000 0001 0807 1581); Ministry of Education, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Chengdu, China (GRID:grid.419897.a) (ISNI:0000 0004 0369 313X) 
 Sichuan University, National Center for Birth Defect Monitoring, West China Second University Hospital, Chengdu, China (GRID:grid.13291.38) (ISNI:0000 0001 0807 1581) 
 The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China (GRID:grid.410649.e) 
 Fuzhou, Fujian Provincial Maternity and Children’s Hospital, Fujian, China (GRID:grid.410649.e) 
 National Human Genetic Resource Center, National Research Institute for Family Planning, Beijing, China (GRID:grid.453135.5) (ISNI:0000 0004 1769 3691) 
 Ministry of Education, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Chengdu, China (GRID:grid.419897.a) (ISNI:0000 0004 0369 313X); Sichuan University, Department of Pediatrics, West China Second University Hospital, Chengdu, China (GRID:grid.13291.38) (ISNI:0000 0001 0807 1581) 
Pages
5312
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3070857520
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.