It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Self-reported shorter/longer sleep duration, insomnia, and evening preference are associated with hyperglycaemia in observational analyses, with similar observations in small studies using accelerometer-derived sleep traits. Mendelian randomization (MR) studies support an effect of self-reported insomnia, but not others, on glycated haemoglobin (HbA1c). To explore potential effects, we used MR methods to assess effects of accelerometer-derived sleep traits (duration, mid-point least active 5-h, mid-point most active 10-h, sleep fragmentation, and efficiency) on HbA1c/glucose in European adults from the UK Biobank (UKB) (n = 73,797) and the MAGIC consortium (n = 146,806). Cross-trait linkage disequilibrium score regression was applied to determine genetic correlations across accelerometer-derived, self-reported sleep traits, and HbA1c/glucose. We found no causal effect of any accelerometer-derived sleep trait on HbA1c or glucose. Similar MR results for self-reported sleep traits in the UKB sub-sample with accelerometer-derived measures suggested our results were not explained by selection bias. Phenotypic and genetic correlation analyses suggested complex relationships between self-reported and accelerometer-derived traits indicating that they may reflect different types of exposure. These findings suggested accelerometer-derived sleep traits do not affect HbA1c. Accelerometer-derived measures of sleep duration and quality might not simply be ‘objective’ measures of self-reported sleep duration and insomnia, but rather captured different sleep characteristics.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 University of Bristol, MRC Integrative Epidemiology Unit, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603); University of Bristol, Population Health Sciences, Bristol Medical School, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603); University of Oxford, Nuffield Department of Population Health, Oxford Population Health, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)
2 University of Bristol, MRC Integrative Epidemiology Unit, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603); University of Bristol, Population Health Sciences, Bristol Medical School, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603)
3 University of Bristol, MRC Integrative Epidemiology Unit, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603); University of Bristol, Population Health Sciences, Bristol Medical School, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603); University College of London, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201)
4 University of Bristol, MRC Integrative Epidemiology Unit, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603); The University of Exeter, College of Medicine and Health, Exeter, UK (GRID:grid.8391.3) (ISNI:0000 0004 1936 8024)
5 Harvard Medical School, Centre for Genomic Medicine, Massachusetts General Hospital, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Broad Institute of MIT and Harvard, Cambridge, USA (GRID:grid.66859.34) (ISNI:0000 0004 0546 1623); Massachusetts General Hospital, Department of Anaesthesia, Critical Care and Pain Medicine, Boston, USA (GRID:grid.32224.35) (ISNI:0000 0004 0386 9924)
6 University of Oxford, Sir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)
7 University of Colorado Boulder, Department of Integrative Physiology, Boulder, USA (GRID:grid.266190.a) (ISNI:0000 0000 9621 4564)
8 University of Colorado Boulder, Department of Psychology & Neuroscience and Institute for Behavioral Genetics, Boulder, USA (GRID:grid.266190.a) (ISNI:0000 0000 9621 4564)
9 University of Helsinki, Institute for Molecular Medicine Finland, Uusimaa, Finland (GRID:grid.7737.4) (ISNI:0000 0004 0410 2071)
10 University of Exeter Medical School, Genetics of Complex Traits, Exeter, UK (GRID:grid.8391.3) (ISNI:0000 0004 1936 8024)
11 University of Manchester, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester, UK (GRID:grid.5379.8) (ISNI:0000 0001 2166 2407)
12 University of Manchester, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester, UK (GRID:grid.5379.8) (ISNI:0000 0001 2166 2407); Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK (GRID:grid.462482.e) (ISNI:0000 0004 0417 0074); University of Manchester, National Institute for Health Research (NIHR) Greater Manchester Patient Safety Translational Research Centre, Manchester, UK (GRID:grid.5379.8) (ISNI:0000000121662407)
13 University of the West Indies, George Alleyne Chronic Disease Research Centre, Caribbean Institute of Health Research, Kingston, Jamaica (GRID:grid.12916.3d) (ISNI:0000 0001 2322 4996); University of Manchester, Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester, UK (GRID:grid.5379.8) (ISNI:0000 0001 2166 2407)
14 King’s College London, Department of Biostatistics and Health Informatics, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764)
15 University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948); John Radcliffe Hospital, NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, Oxford, UK (GRID:grid.8348.7) (ISNI:0000 0001 2306 7492)
16 Harvard Medical School, Centre for Genomic Medicine, Massachusetts General Hospital, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Broad Institute of MIT and Harvard, Cambridge, USA (GRID:grid.66859.34) (ISNI:0000 0004 0546 1623); Massachusetts General Hospital, Department of Anaesthesia, Critical Care and Pain Medicine, Boston, USA (GRID:grid.32224.35) (ISNI:0000 0004 0386 9924); Harvard Medical School, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X)
17 Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK (GRID:grid.462482.e) (ISNI:0000 0004 0417 0074); NIHR Manchester Biomedical Research Centre, Diabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK (GRID:grid.454377.6) (ISNI:0000 0004 7784 683X); University of Manchester, Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester, UK (GRID:grid.5379.8) (ISNI:0000 0001 2166 2407)
18 University of Bristol, MRC Integrative Epidemiology Unit, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603); University of Bristol, Population Health Sciences, Bristol Medical School, Bristol, UK (GRID:grid.5337.2) (ISNI:0000 0004 1936 7603); University Hospitals Bristol NHS Foundation Trust and The University of Bristol, National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, Bristol, UK (GRID:grid.410421.2) (ISNI:0000 0004 0380 7336)