Abstract

Background

Chronic liver disease is a common and important clinical problem. Hepatorenal syndrome (HRS) is a life threatening complication. Serum creatinine (Cr) remains the only conventional indicator of renal function. However, the interpretation of serum Cr level can be confounded by malnutrition and reduced muscle mass often observed in patients with severe liver disease. Here, we present a cross-sectional study to explore the sensitivity and specificity of other markers as urinary KIM-1 and NGAL for cases of HRS.

Methods

Cross-sectional study was conducted on 88 patients who were admitted to Alexandria main university hospital. Enrolled patients were divided in two groups; group 1: patients with advanced liver cirrhosis (child B and C) who have normal kidney functions while group 2: patients who developed HRS. Stata© version 14.2 software package was used for analysis.

Results

Group 1 included 18 males and 26 females compared to 25 males and 19 females in group 2 (p = 0.135). Only the urinary KIM-1 showed a statistically significant difference between both groups in the multivariate logistic regression analysis adjusted for gender, serum bilirubin, serum albumin, INR, serum K, AST and ALT levels.

Conclusion

In conclusion, our study aligns with prior research, as seen in the consistent findings regarding Urinary NGAL elevation in cirrhotic patients with AKI. Urinary KIM-1, independent of Urinary NGAL, may have a role in precisely distinguishing between advanced liver cirrhosis and HRS and merits further exploration.

Details

Title
The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients
Author
Mohamed Adel Abd Elaziz 1 ; Asmaa Mustafa Gouda Elewa 2 ; Dina Zaki Mohamed Zaki Abdel Hamid 3 ; Nohier Essam Soliman Ahmed Hassan 4 ; Csongrádi, Éva 5 ; Emad Hamdy Hamouda Mohammed 6 ; Mohammed Abdel Gawad 7   VIAFID ORCID Logo 

 Tropical Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt 
 Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt 
 Clinical Pharmacist at Alexandria Hepatology, Gastroenterology and Fever Hospital, Egypt 
 Clinical Pharmacist at Zamzam Hospital, Alexandria, Egypt 
 Faculty of Medicine, University of Debrecen, Debrecen, Hungary 
 Lecturer of Critical Care, Faculty of Medicine, Alexandria University, Alexandria, Egypt 
 Nephrology Unit, Internal Medicine Department, School of Medicine, Newgiza (NGU) University, Giza, Egypt 
Publication year
2024
Publication date
Dec 2024
Publisher
Taylor & Francis Ltd.
ISSN
0886022X
e-ISSN
15256049
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3073446891
Copyright
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.