Abstract

Blood-based biomarkers of Alzheimer disease (AD) may facilitate testing of historically under-represented groups. The Study of Race to Understand Alzheimer Biomarkers (SORTOUT-AB) is a multi-center longitudinal study to compare AD biomarkers in participants who identify their race as either Black or white. Plasma samples from 324 Black and 1,547 white participants underwent analysis with C2N Diagnostics’ PrecivityAD test for Aβ42 and Aβ40. Compared to white individuals, Black individuals had higher average plasma Aβ42/40 levels at baseline, consistent with a lower average level of amyloid pathology. Interestingly, this difference resulted from lower average levels of plasma Aβ40 in Black participants. Despite the differences, Black and white individuals had similar longitudinal rates of change in Aβ42/40, consistent with a similar rate of amyloid accumulation. Our results agree with multiple recent studies demonstrating a lower prevalence of amyloid pathology in Black individuals, and additionally suggest that amyloid accumulates consistently across both groups.

Plasma samples from 324 Black and 1,547 white participants underwent analysis with C2N Diagnostics’ Precivity AD test for Aβ42 and Aβ40. Compared to white individuals, Black individuals had higher average plasma Aβ42/40 levels at baseline, consistent with a lower average level of amyloid pathology.

Details

Title
Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals
Author
Xiong, Chengjie 1 ; Luo, Jingqin 2   VIAFID ORCID Logo  ; Wolk, David A. 3 ; Shaw, Leslie M. 4 ; Roberson, Erik D. 5   VIAFID ORCID Logo  ; Murchison, Charles F. 5 ; Henson, Rachel L. 6 ; Benzinger, Tammie L. S. 7   VIAFID ORCID Logo  ; Bui, Quoc 8 ; Agboola, Folasade 8 ; Grant, Elizabeth 8 ; Gremminger, Emily N. 8 ; Moulder, Krista L. 6 ; Geldmacher, David S. 5 ; Clay, Olivio J. 9 ; Babulal, Ganesh 6 ; Cruchaga, Carlos 6   VIAFID ORCID Logo  ; Holtzman, David M. 6   VIAFID ORCID Logo  ; Bateman, Randall J. 6   VIAFID ORCID Logo  ; Morris, John C. 6 ; Schindler, Suzanne E. 6   VIAFID ORCID Logo 

1  Washington University, Division of Biostatistics, St. Louis, USA (GRID:grid.34477.33) (ISNI:0000 0001 2298 6657); Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002) 
2  Washington University School of Medicine, Division of Public Health Sciences, Department of Surgery, St. Louis, USA (GRID:grid.4367.6); Washington University School of Medicine, Siteman Cancer Center Biostatistics and Qualitative Research Shared Resource, St. Louis, USA (GRID:grid.4367.6) 
3  University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA (GRID:grid.25879.31) (ISNI:0000 0004 1936 8972) 
4  University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA (GRID:grid.25879.31) (ISNI:0000 0004 1936 8972); University of Pennsylvania, Department of Pathology and Laboratory Medicine, Philadelphia, USA (GRID:grid.25879.31) (ISNI:0000 0004 1936 8972) 
5  University of Alabama at Birmingham, Alzheimer’s Disease Center, Department of Neurology, Birmingham, USA (GRID:grid.265892.2) (ISNI:0000 0001 0634 4187) 
6  Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002) 
7  Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University, Mallinckrodt Institute of Radiology, St. Louis, USA (GRID:grid.34477.33) (ISNI:0000 0001 2298 6657) 
8  Washington University, Division of Biostatistics, St. Louis, USA (GRID:grid.34477.33) (ISNI:0000 0001 2298 6657) 
9  University of Alabama at Birmingham, Alzheimer’s Disease Center, Department of Neurology, Birmingham, USA (GRID:grid.265892.2) (ISNI:0000 0001 0634 4187); University of Alabama at Birmingham, Department of Psychology, Birmingham, USA (GRID:grid.265892.2) (ISNI:0000 0001 0634 4187) 
Pages
5539
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-024-49859-w
ProQuest document ID
3074881721
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.