Abstract

The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer Disease. Over more than 40 years, research volunteers have been recruited to participate in cognitive, neuropsychologic, imaging, fluid biomarkers, genomic and multi-omic studies. Tissue and longitudinal data collected to foster, facilitate, and support research on dementia and aging. The Genetics and high throughput -omics core (GHTO) have collected of more than 26,000 biological samples from 6,625 Knight-ADRC participants. Samples available include longitudinal DNA, RNA, non-fasted plasma, cerebrospinal fluid pellets, and peripheral blood mononuclear cells. The GHTO has performed deep molecular profiling (genomic, transcriptomic, epigenomic, proteomic, and metabolomic) from large number of brain (n = 2,117), CSF (n = 2,012) and blood/plasma (n = 8,265) samples with the goal of identifying novel risk and protective variants, identify novel molecular biomarkers and causal and druggable targets. Overall, the resources available at GHTO support the increase of our understanding of Alzheimer Disease.

Details

Title
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center
Author
Fernandez, Maria Victoria 1 ; Liu, Menghan 2 ; Beric, Aleksandra 2   VIAFID ORCID Logo  ; Johnson, Matt 2 ; Cetin, Arda 2   VIAFID ORCID Logo  ; Patel, Maulik 2 ; Budde, John 2   VIAFID ORCID Logo  ; Kohlfeld, Pat 2   VIAFID ORCID Logo  ; Bergmann, Kristy 2 ; Lowery, Joseph 2 ; Flynn, Allison 2 ; Brock, William 2 ; Sanchez Montejo, Brenda 2 ; Gentsch, Jen 2 ; Sykora, Nicholas 2 ; Norton, Joanne 2 ; Valdez, Olga 2 ; Gorijala, Priyanka 2 ; Sanford, Jessie 2 ; Sun, Yichen 2 ; Wang, Ciyang 2 ; Western, Dan 2   VIAFID ORCID Logo  ; Timsina, Jigyasha 2 ; Mangetti Goncalves, Tassia 3 ; Do, Anh N. 4 ; Sung, Yun Ju 2 ; Zhao, Guoyan 5   VIAFID ORCID Logo  ; Morris, John C. 6 ; Moulder, Krista 6 ; Holtzman, David M. 7   VIAFID ORCID Logo  ; Bateman, Randall J. 8   VIAFID ORCID Logo  ; Karch, Celeste 9   VIAFID ORCID Logo  ; Hassenstab, Jason 6 ; Xiong, Chengjie 10 ; Schindler, Suzanne E. 6   VIAFID ORCID Logo  ; Balls-Berry, Joyce (Joy) 6 ; Benzinger, Tammie L. S. 11 ; Perrin, Richard J. 12   VIAFID ORCID Logo  ; Denny, Andrea 6 ; Snider, B. Joy 7 ; Stark, Susan L. 13 ; Ibanez, Laura 14 ; Cruchaga, Carlos 15   VIAFID ORCID Logo 

1  Washington University School of Medicine, Department of Psychiatry, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, NeuroGenomics and Informatics Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); ACE Alzheimer Center, Research Center and Memory Clinic, Barcelona, Spain (GRID:grid.4367.6) 
2  Washington University School of Medicine, Department of Psychiatry, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, NeuroGenomics and Informatics Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002) 
3  Washington University School of Medicine, Department of Genetics, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002) 
4  Washington University School of Medicine, Department of Psychiatry, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, NeuroGenomics and Informatics Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Division of Biostatistics, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002) 
5  Washington University School of Medicine, Department of Genetics, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Pathology and Immunology Department, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002) 
6  Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Knight Alzheimer Disease Research Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002) 
7  Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Knight Alzheimer Disease Research Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Hope Center for Neurological Disorders, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002) 
8  Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Knight Alzheimer Disease Research Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Hope Center for Neurological Disorders, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA (GRID:grid.4367.6) 
9  Washington University School of Medicine, Department of Psychiatry, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Knight Alzheimer Disease Research Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Hope Center for Neurological Disorders, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA (GRID:grid.4367.6) 
10  Washington University School of Medicine, Division of Biostatistics, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Knight Alzheimer Disease Research Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA (GRID:grid.4367.6) 
11  Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Knight Alzheimer Disease Research Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA (GRID:grid.4367.6); Washington University School of Medicine, Radiology Department, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002) 
12  Washington University School of Medicine, Pathology and Immunology Department, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Knight Alzheimer Disease Research Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA (GRID:grid.4367.6) 
13  Washington University School of Medicine, Knight Alzheimer Disease Research Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Neurology and Social Work, Occupational Therapy, St. Louis, USA (GRID:grid.4367.6) 
14  Washington University School of Medicine, Department of Psychiatry, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, NeuroGenomics and Informatics Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA (GRID:grid.4367.6) 
15  Washington University School of Medicine, Department of Psychiatry, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, NeuroGenomics and Informatics Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Department of Genetics, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Department of Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Knight Alzheimer Disease Research Center, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Hope Center for Neurological Disorders, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA (GRID:grid.4367.6) 
Pages
768
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20524463
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41597-024-03485-9
ProQuest document ID
3079613089
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.