It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Pancreatic cancer presents a critical health issue characterized by low survival rates. Identifying risk factors in specific populations, such as those with diabetes, is crucial for early detection and improved outcomes. This study aimed to identify risk factors for pancreatic cancer in diabetic patients using a longitudinal cohort from the Shizuoka Kokuho database, spanning April 2012 to September 2021. Diabetic patients were identified and monitored for the onset of pancreatic cancer. Factors analyzed included age, sex, the Elixhauser comorbidity index, and specific comorbidities. Statistical analyses involved univariate and multivariate Cox proportional hazards regression. The study identified 212,775 as diabetic patients and 1755 developed pancreatic cancer during the period. The annual incidence rate of pancreatic cancer in this group was 166.7 cases per 100,000 person-years. The study identified older age, male sex, a history of liver disease, chronic pancreatitis, and pancreatic cystic lesions as significant risk factors for pancreatic cancer in diabetic patients. The study also highlighted the absence of a significant association between diabetes type or diabetic complications and the onset of pancreatic cancer. These findings may aid in the early diagnosis of pancreatic cancer in diabetic patients and may inform revisions in screening practices in diabetic patients.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Keio University School of Medicine, Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Tokyo, Japan (GRID:grid.26091.3c) (ISNI:0000 0004 1936 9959); Shizuoka General Hospital, Department of Gastroenterology, Shizuoka, Japan (GRID:grid.415804.c) (ISNI:0000 0004 1763 9927); Shizuoka Graduate University of Public Health, Graduate School of Public Health, Shizuoka, Japan (GRID:grid.518453.e) (ISNI:0000 0004 9216 2874)
2 Shizuoka Graduate University of Public Health, Graduate School of Public Health, Shizuoka, Japan (GRID:grid.518453.e) (ISNI:0000 0004 9216 2874)
3 Shizuoka General Hospital, Department of Diabetes and Endocrinology, Shizuoka, Japan (GRID:grid.415804.c) (ISNI:0000 0004 1763 9927)
4 Shizuoka General Hospital, Department of Gastroenterology, Shizuoka, Japan (GRID:grid.415804.c) (ISNI:0000 0004 1763 9927)
5 Keio University, Center for Preventive Medicine, Tokyo, Japan (GRID:grid.26091.3c) (ISNI:0000 0004 1936 9959)
6 Keio University School of Medicine, Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Tokyo, Japan (GRID:grid.26091.3c) (ISNI:0000 0004 1936 9959)
7 Shizuoka Graduate University of Public Health, Graduate School of Public Health, Shizuoka, Japan (GRID:grid.518453.e) (ISNI:0000 0004 9216 2874); Shizuoka General Hospital, Research Support Center, Shizuoka, Japan (GRID:grid.415804.c) (ISNI:0000 0004 1763 9927)