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© 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Aim

To investigate the association between vitamin D3 level and oxidative stress biomarkers such as Heat Shock Protein 70 (HSP70), ferric reducing ability of plasma (FRAP), advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) in patients with Type 2 diabetes.

Method

In this cross-sectional study, 54 patients including 32 females and 22 males with a mean age of 54.92 ± 11.37 years with T2D attending the diabetes clinic from 2021 to 2022 were included. According to the average level of vitamin D in this population (14.91), they were divided into two groups with vitamin D ≤15 ng/mL and vitamin D >15 ng/mL. Multivariate regression analysis was conducted to evaluate the relationship between vitamin D and AOPP, HSP and FRAP parameters. The correlation between vitamin D and other variables was evaluated via the Pearson correlation test.

Result

Vitamin D level had a positive relation with FRAP (β = 0.32, p = 0.017) and HSP (β = 0.39, p = 0.003), but had a negative relation with AOPP (β = −0.30, p = 0.02). The level of 2hPP also had a negative relation with the level of vitamin D (β = −0.33, p = 0.03). There was not any relationship between the level of vitamin D and AGEs or other variables. After adjusting for multiple confounders for the multivariate regression model, HSP remained significant.

Conclusion

This research indicates the relationship between vitamin D levels and oxidative stress biomarkers in patients with Type 2 diabetes.

Details

Title
Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products
Author
Hashemi, Nazanin 1 ; Sahar Karimpour Reyhan 1 ; Qahremani, Reihane 1 ; Seifouri, Kiana 1 ; Tavakoli, Meraj 1 ; Seyedi, Seyed Arsalan 1 ; Ghaemi, Farahnaz 2 ; Abbaszadeh, Mahsa 1 ; Esteghamati, Alireza 1 ; Nakhjavani, Manouchehr 1   VIAFID ORCID Logo  ; Mirmiranpour, Hossein 1 ; Rabizadeh, Soghra 1 

 Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran 
 Department of Biology, Kerman Branch, Islamic Azad University, Kerman, Iran 
Section
RESEARCH ARTICLE
Publication year
2024
Publication date
Jul 2024
Publisher
John Wiley & Sons, Inc.
e-ISSN
23989238
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3084294350
Copyright
© 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.