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© 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background

Few population-based studies have described allergic rhinitis (AR) according to the Allergic Rhinitis and its Impact on Asthma (ARIA) classification, and none have assessed the impact of asthma on this classification. Our aims were to 1) describe AR according to four ARIA classes and 2) within each of the four ARIA classes, compare participants with AR alone versus those with AR and asthma.

Methods

Cross-sectional analyses were performed using data from the 2014 annual follow-up questionnaire of the French adult population-based cohort Constances. Current AR was defined by the report of sneezing, runny, or blocked nose in the last 12 months and the report of nasal allergies. Following ARIA recommendations, rhinitis was classified according to its severity (mild or moderate-severe) and duration (intermittent or persistent). Ever asthma was also defined by a questionnaire.

Results

Among the 4675 participants with AR (57% women, mean age 50.2 ± 12.7 years), 44% were classified as mild/intermittent, 16% mild/persistent, 25% moderate-severe/intermittent, and 15% moderate-severe/persistent. Within each of the four ARIA classes, compared to participants with rhinitis alone, participants with rhinitis and asthma had significantly more severe symptoms, more conjunctivitis, a higher mean eosinophil count and more treatments with intra-nasal corticosteroids and oral antihistamines co-medication.

Conclusions

This is a paradigm shift study as for the first time this large population-based study in adults showed that asthma status has a profound effect on the ARIA classification. Rhinitis alone and rhinitis with asthma represent two distinct phenotypes. These results reinforce the need to include asthma status in the ARIA classification and guidelines.

Details

Title
Asthma is associated with increased severity and duration of rhinitis: A study with the Allergic Rhinitis and its Impact on Asthma classes in the Constances cohort
Author
Savouré, Marine 1   VIAFID ORCID Logo  ; Bousquet, Jean 2   VIAFID ORCID Logo  ; Leynaert, Bénédicte 3   VIAFID ORCID Logo  ; Ribet, Céline 4   VIAFID ORCID Logo  ; Goldberg, Marcel 4   VIAFID ORCID Logo  ; Zins, Marie 4   VIAFID ORCID Logo  ; Jacquemin, Bénédicte 5   VIAFID ORCID Logo  ; Nadif, Rachel 3   VIAFID ORCID Logo 

 Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Equipe d’Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France; French Environment and Energy Management Agency, Angers, France 
 Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Equipe d’Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France; Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany; Department of Dermatology and Allergy, Comprehensive Allergy Center, Berlin Institute of Health, Berlin, Germany; Centre Hospitalier Universitaire, Montpellier, France; MASK-air, Montpellier, France 
 Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Equipe d’Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France 
 Université Paris-Cité, Université Paris-Saclay, UVSQ, Inserm, UMS 11 Cohortes Epidémiologiques en population, Villejuif, France 
 Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en Santé, environnement et travail) - UMR_S 1085, Rennes, France 
Section
ORIGINAL ARTICLE
Publication year
2023
Publication date
Nov 2023
Publisher
John Wiley & Sons, Inc.
e-ISSN
20457022
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3084304419
Copyright
© 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.