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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Torque Teno Virus (TTV) is a ubiquitous component of the human virome, not associated with any disease. As its load increases when the immune system is compromised, such as in kidney transplant (KT) recipients, TTV load monitoring has been proposed as a method to assess immunosuppression. In this prospective study, TTV load was measured in plasma and urine samples from 42 KT recipients, immediately before KT and in the first 150 days after it. Data obtained suggest that TTV could be a relevant marker for evaluating immune status and could be used as a guide to predict the onset of infectious complications in the follow-up of KT recipients. Since we observed no differences considering distance from transplantation, while we found a changing trend in days before viral infections, we suggest to consider changes over time in the same subjects, irrespective of time distance from transplantation.

Details

Title
Torque Teno Virus: A Promising Biomarker in Kidney Transplant Recipients
Author
Sara Dal Lago 1 ; Brani, Paola 2   VIAFID ORCID Logo  ; Ietto, Giuseppe 2   VIAFID ORCID Logo  ; Daniela Dalla Gasperina 2   VIAFID ORCID Logo  ; Gianfagna, Francesco 3   VIAFID ORCID Logo  ; Giaroni, Cristina 2   VIAFID ORCID Logo  ; Bosi, Annalisa 4   VIAFID ORCID Logo  ; Francesca Drago Ferrante 5 ; Genoni, Angelo 2 ; Hafza, Zahira Manzoor 2 ; Ambrosini, Andrea 1 ; De Cicco, Marco 1 ; Corradina Dina Quartarone 1 ; Khemara, Sara 1 ; Carcano, Giulio 2   VIAFID ORCID Logo  ; Maggi, Fabrizio 6   VIAFID ORCID Logo  ; Baj, Andreina 2   VIAFID ORCID Logo 

 Nephrology Department, ASST Sette Laghi, University of Insubria, 21100 Varese, Italy 
 Department of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy 
 Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy; Mediterranea Cardiocentro, 80122 Napoli, Italy 
 Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy 
 Laboratory of Microbiology, ASST Sette Laghi, 21100 Varese, Italy 
 Laboratory of Virology, National Institute for Infectious Diseases L. Spallanzani—IRCCS, 00149 Rome, Italy 
First page
7744
Publication year
2024
Publication date
2024
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3084930878
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.